摘要
目的:探讨急性脑梗死患者血清IL-23、IL-35水平与颈动脉粥样硬化斑块稳定性的关系.方法:选取124例急性脑梗死患者,按颈动脉超声检查结果分为不稳定斑块组、稳定斑块组及无斑块组;选取63例健康人群为对照组.对比各组血清IL-23、IL-35水平.结果:急性脑梗死组血清IL-35水平(18.8±6.7)ng/mL显著高于对照组(8.7±4.1)ng/mL两者间差异具有统计学意义(P<0.01);急性脑梗死组血清IL-23水平(24.3±4.8)ng/mL均显著高于对照组(8.4±1.6)ng/mL,两者间差异具有统计学意义(P<0.01).不稳定斑块组患者血清IL-35水平(22.3±5.8)ng/mL显著高于稳定斑块组患者血清IL-35水平(15.3±1.6)ng/mL,两者间差异具有统计学意义(P<0.01);不稳定斑块组患者和稳定斑块组患者血清IL-35水平(22.3±5.8)ng/mL和(15.3±1.6)ng/mL显著高于无斑块组(10.7±4.1)ng/mL,两者间差异具有统计学意义(P<0.01);不稳定斑块组患者血清IL-23水平(36.9±6.4)ng/mL显著高于稳定斑块组患者血清IL-23水平(23.4±4.7)ng/mL,两者间差异具有统计学意义(P<0.01);不稳定斑块组患者和稳定斑块组患者血清IL-23水平(36.9±6.4)ng/mL和(23.4±4.7)ng/mL显著高于无斑块组(11.4±1.6)ng/mL,两者间差异具有统计学意义(P<0.01);结论:急性脑梗死患者血清IL-23、IL-35水平可能和颈动脉粥样硬化斑块稳定性有关.
Objective: To investigate the relationship between the serum levels of IL-23 and IL-35 and the stability of carotid atherosclerotic plaques in patients with acute cerebral infarction. Methods: 124 patients with acute cerebral infarction were divided into unstable plaque group, stable plaque group and non-plaque group according to the results of carotid ultrasonography, and 63 healthy people were selected as control group. Serum levels of IL-23 and IL-35 were compared in each group. Results: The level of serum IL-35 (18.8±6.7) ng/ml in the acute cerebral infarction group was significantly higher than that in the control group (8.7±4.1) ng/ml (P<0.01);the level of serum IL-23 (24.3±4.8) ng/ml in the acute cerebral infarction group was significantly higher than that in the control group (8.4+1.6) ng/ml (P<0.01). Academic significance (P<0.01). Serum IL-35 level (22.3±5.8) ng/ml in patients with unstable plaque was significantly higher than that in patients with stable plaque (15.3±1.6) ng/ml in patients with unstable plaque (P<0.01);serum IL-35 level (22.3±5.8) ng/ml and (15.3+1.6) ng/ml in patients with unstable plaque and patients with stable plaque were significantly higher than those in patients without plaque (10.7±4.1) ng/ml in patients with unstable plaque (P<0.01). The serum IL-23 level (36.9+6.4) ng/ml in unstable plaque group was significantly higher than that in stable plaque group (23.4±4.7) ng/ml (P<0.01);the serum IL-23 level (36.9±6.4) ng/ml and (23.4±4.7) ng/ml in unstable plaque group and stable plaque group were significantly higher than those in non-plaque group (11.4±1.6 ) ng/ml, the difference was statistically significant (P<0.01). Conclusion: The serum levels of IL-23 and IL-35 in patients with acute cerebral infarction may be related to the stability of carotid atherosclerotic plaque.
作者
王琳
齐立
何伟
李荣宗
蒋文贤
WANG Lin;QI Li;HE Wei(924 Hospital of PLA Joint Logistics Support Force, Guangxi Guilin 541000, China)
出处
《河北医学》
CAS
2019年第8期1312-1316,共5页
Hebei Medicine
基金
广西壮族自治区桂林市科学研究与技术开发项目,(编号:20170109-32)
广西中医药民族医药传承创新专项课题,(编号:GZLC16-45)
