摘要
目的:探讨改良的简化MDRD方程估算肾小球滤过率(GFR)与IgA肾病病理损伤的相关性。方法:回顾分析IgA 肾病病人临床、病理学资料。GFR由改良的简化MDRD方程估算(改良的简化MDRD-eGFR)。肾脏病理损伤按照Katafuchi半定量积分标准进行评分并按照Lee′s分级标准。结果:随着病理学损伤加重,改良的简化MDRD-eGFR水平逐渐降低( P < 0.05 );Katafuchi积分、肾小球硬化、肾小管间质损伤及肾血管病变与改良的简化MDRD-eGFR均存在相关性( P <0.01)。当改良的简化MDRD-eGFR≥90 mL·min^-1·1.73 m^-2 时,此种相关性消失,但病人均存在一定程度病理损伤。结论:改良的简化MDRD方程估算肾小球滤过率与IgA肾病肾脏病理损伤情况关系密切,当其<90 mL·min^-1 ·1.73 m^-2 对肾小管间质损伤情况的评估预测价值较大。
Objective: To investigate the correlation between glomerular filtration rate estimated by modified simplified MDRD equation(MDRD-eGFR) and pathological damage caused by IgA nephropathy. Methods: The clinical and pathological data and modified simplified MDRD-eGFR in patients with IgA nephropathy were retrospectively analyzed.The renal pathological injury was graded according to Katafuchi semi-quantitative score standard and Lee′s grading standard. Results: With the aggravation of pathological injury,the level of modified simplified MDRD-eGFR decreased gradually( P <0.05).The Katafuchi score,glomerulosclerosis,tubular interstitial injury and renal vasculopathy were correlated with modified simplified MDRD-eGFR( P <0.01).When the modified simplified MDRD-eGFR was more than or equal to 90 mL·min^-1·1.73 m^-2 ,the correlation disappeared,but the patients had some degree of pathological injury. Conclusions: The modified simplified MDRD-eGFR is closely related to the renal pathological damage in IgA nephropathy.When the modified simplified MDRD-eGFR is less than 90 mL·min^-1 ·1.73 m^-2 ,the prediction value of which in renal tubulointerstitial injury is great.
作者
任丽
张从利
潘艳
丁梦阳
孙俊杰
REN Li;ZHANG Cong-li;PAN Yan;DING Meng-yang;SUN Jun-jie(School of Laboratory Medicine,Bengbu Medical College,Bengbu Anhui 233030;Department of Anesthesiology,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China;Department of Nephrology,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China)
出处
《蚌埠医学院学报》
CAS
2019年第7期908-910,共3页
Journal of Bengbu Medical College
基金
蚌埠医学院自然科学重点项目(BYKY1718ZD)
蚌埠医学院科技发展基金项目(BYKF1789)
安徽省大学生创新训练项目(201710367043)
关键词
IGA肾病
改良的简化MDRD方程
肾小球滤过率
病理损伤
IgA nephropathy
modified simplified MDRD equation
glomerular filtration rate
pathological damage
