摘要
目的分析重复经颅磁刺激(rTMS)联合利培酮治疗精神分裂症伴强迫症的临床疗效。方法 80例精神分裂症伴强迫症患者,按照入院顺序分为对照组和观察组,每组40例。对照组患者采用利培酮治疗,观察组患者采用重复经颅磁刺激联合利培酮治疗。比较两组患者的临床疗效、阳性与阴性症状量表(PANSS)减分率、耶鲁-布朗强迫症状量表(Y-BOCS)减分率、利培酮负荷剂量及不良反应发生情况。结果观察组患者精神分裂症、强迫症的临床疗效均优于对照组,差异有统计学意义(P<0.05)。第16周,观察组患者PANSS减分率、Y-BOCS减分率分别为(72.5±14.2)%、(67.1±11.2)%,均高于对照组的(65.6±11.8)%、(45.7±10.8)%,差异有统计学意义(P<0.05)。两组患者利培酮负荷剂量比较差异无统计学意义(P>0.05)。观察组患者椎体外系反应发生率为35.0%,高于对照组的15.0%,差异有统计学意义(P<0.05)。结论采用重复经颅磁刺激联合利培酮治疗精神分裂症伴强迫症可以提高临床疗效,但是可能增加不良反应发生风险。
Objective To analyze the clinical efficacy of repetitive transcranial magnetic stimulation(rTMS) combined with risperidone in the treatment of schizophrenia complicated with obsessive-compulsive disorder. Methods A total of 80 patients with schizophrenia complicated with obsessive-compulsive disorder were divided by admission order into control group and observation group, with 40 cases in each group. The controlgroup was treated with risperidone, and the observation group was treated with repetitive transcranial magnetic stimulation combined with risperidone. Comparison were made on clinical efficacy, reduction rate of positive and negative symptoms scale(PANSS), reduction rate of Yale-Brown obsessive-compulsive symptoms scale(Y-BOCS), risperidone loading dose and occurrence of adverse reactions between the two groups. Results The observation group had better clinical efficacy of schizophrenia and obsessive-compulsive disorder than the control group, and their difference was statistically significant(P<0.05). At the 16 th week, the observation group had higher reduction rate of PANSS and Y-BOCS respectively as(72.5±14.2)% and(67.1±11.2)% than(65.6±11.8)% and(45.7±10.8)% in the control group. Their difference was statistically significant(P<0.05). There was no statistically significant difference in risperidone loading dose between the two groups(P>0.05). The observation group had higher incidence of extravertebral system reaction as 35.0% than 15.0% in the control group, and the difference was statistically significant(P<0.05). Conclusion Repetitive transcranial magnetic stimulation combined with risperidone can improve the clinical efficacy, but may increase the risk of adverse reactions.
作者
秦海燕
QIN Hai-yan(Department of Psychological Rehabilitation, Liaocheng Forth People's Hospital,Liaocheng 252000,China)
出处
《中国实用医药》
2019年第22期9-11,共3页
China Practical Medicine
关键词
重复经颅磁刺激
利培酮
精神分裂症
强迫症
Repetitive transcranial magnetic stimulation
Risperidone
Schizophrenia
Obsessive - compulsive disorder
