摘要
目的:分析奥氮平在基层精神病专科医院使用中引起的药物不良反应(ADR)的特点和规律,为临床合理用药提供参考。方法:抽取医院2016年1月—2018年6月间在线上报国家药品不良反应监测中心被确认的42例奥氮平致ADRs报告,分析其奥氮平致ADRs的特点和规律。结果:42例ADRs患者中,其中神经系统损害24例占57.16%,最常见临床表现为静坐不能、感觉异常、椎体外系反应等症状;其次为代谢内分泌系统5例占11.90%,临床表现为水肿、代谢絮乱和体质量增加;奥氮平剂量在20 mg/d时发生ADRs的例数为最多;使用奥氮平出现不良反应后经治疗好转或痊愈41例占97.62%。结论:和经典抗精神病药物相比,奥氮平具有良好的安全性,但临床使用过程中对其引起ADR仍应引起足够重视并加强监测。
Objective: To observe the characteristics and regularity of adverse drug reactions(ADR) caused by olanzapine in primary psychiatric hospitals, and to provide a reference for clinical rational drug use. Methods: From January2016 to June 2018, 42 cases of ADRs caused by olanzapine were selected to report to the National Adverse Drug Reaction Monitoring Center, and the characteristics and rules of olanzapine-induced ADRs were analyzed.Results: Among the 42 patients with ADRs, 24 of them had neurological damage accounting for 57.16%. Secondly, 5 cases of metabolic endocrine system accounted for 11.90%. The clinical manifestations were edema, metabolic disorder and increased body mass.The most cases of ADRs occurred by olanzapine at 20 mg/d. After the adverse reactions by olanzapine, 41 cases(97.62%) improved or recovered after treatment. Conclusion: Olanzapine has good safety compared with classical antipsychotic drugs, but enough attention should be paid to the ADRs induced by olanzapine during clinical use and monitoring should be strengthened.
作者
施薇华
SHI Wei-hua(Changshu No.3 People's Hospital, Changshu Jiangsu 215500, CHina)
出处
《抗感染药学》
2019年第2期272-275,共4页
Anti-infection Pharmacy
关键词
奥氮平
药物不良反应
相关因素
特点和规律
olanzapine
adverse drug reactions
related factors
characteristics and regularity
