摘要
目的 研究灌胃后酸模素在大鼠体内的药代动力学特征。方法SD大鼠灌胃给予酸模素(100mg·kg -1 )后,用HPLC法测定其血药浓度,并采用DAS 2.1得出其主要药代动力学参数。结果 大鼠灌胃后T max 为3.89±0.32h,V z/F 为19.29±2.24mL·kg -1 ,t 1/2 z 和MRT (0-∞)分别为2.19±0.22h和6.58±0.23h。结论 药代动力学参数表明酸模素在大鼠体内吸较慢、分布广、消除快。
OBJECTIVE To study the pharmacokinetic characteristics of nepod in in rat after oral administration. METHODS Rats were oral adm inistration nepodin (100mg·kg -1 ),the concentration of nepodin at differe n t time was determined by HPLC,the main pharmacokinetic parameters were studied by DAS 2.1. RESULTS The pharmacokinetic parameters T max ,V z/F ,t 1/2 z and MRT (0-∞) were 3.89±0.32h,19.29±2.24mL· kg -1 ,2.19±0.22h and 6.58±0.23h respectively. CONCLUSION The pharmacokinetic parameters show that absorption of nepodin is slow,wide distribution and elimination is fast in rat.
作者
李文
罗莉丹
陈达林
廖禹东
LI Wen;LUO Li-dan;CHEN Da-lin;LIAO Yu-dong(Gangnan health vocational college,Ganzhou 341000,China;Gan zhou maternal and child health hospital,Ganzhou 341000,China)
出处
《海峡药学》
2019年第7期8-10,共3页
Strait Pharmaceutical Journal
基金
江西省卫生厅中医药科研基金课题(编号:2014A145)
