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草乌提取物乌头碱和新乌头碱的透皮速率测定 被引量:15

Percutaneous absorption of aconitine and mesaconitine in extracts of Radix Aconitum kusnezoffii
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摘要 目的:测定草乌提取物中乌头碱、新乌头碱的透皮速率。方法:用改良Franz扩散池法收集草乌提取物的透皮接受液,用高效液相色谱法测定其中乌头碱、新乌头碱的透皮速率。结果:在促透剂氮酮和丙二醇各为4%的条件下,浓度为600mg/ml的草乌提取物中乌头碱、新乌头碱24h的累积渗透量分别为165.819和487.747μg/cm2;透皮速率常数分别为18.391和78.805μg·cm-2·h-1。结论:草乌提取物中乌头碱、新乌头碱在氮酮和丙二醇的促透作用下能较好地透过大鼠皮肤,透皮吸收过程符合Higuchi方程。 Objective: This study was conducted to evaluate the percutaneous absorption of aconitine and mesaconitine in extracts of Radix Aconitum kusnezoffii. Methods: The extracts of Radix Aconitum kusnezoffii were collected by using Franz diffusion cells after permeation through the skin of rats. Then rate constants of skin permeation of aconitine and mesaconitine were determined by high-performance liquid chromatography (HPLC). Results: Under the condition that the concentrations of azone and propylene glycol were both 4%, the cumulative doses of skin permeation (Q) of mesaconitine and aconitine in the extracts of Radix Aconitum kusnezoffii (600 mg/ml) for 24 hours were 165. 819 and 487. 747 μg/cm^2 respectively, and their rate constants of skin permeation were 18. 391 and 78. 805 μg·cm^2·h^-1 respectively. Conclusion: The aconitine and mesaconitine in the extracts of Radix Aconitum kusnezoffii can penetrate well through the skin of rats. Propylene glycol and azone can promote this penetration effects. The formula of skin permeation of mesaconitine and aconitine is in accordance with Higuchi equation and there is a linear relationship between Q and t1/2.
出处 《中西医结合学报》 CAS 2006年第1期68-72,共5页 Journal of Chinese Integrative Medicine
基金 国家中医药管理局科研基金资助项目(No.2000-J-P-27)
关键词 中草药提取物 草乌 新乌头碱 乌头碱 透皮吸收 高效液相色谱 plant extracts, Chinese Radix Aconitum kusnezoffii mesaconitine aconitine percutaneous absorption high-performance liquid chromatography
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