摘要
目的探讨龙生蛭胶囊联合丁苯酞治疗脑梗死的临床疗效及对血清炎症因子的影响。方法将100例脑梗死患者分为观察组和对照组。对照组采用丁苯酞治疗。观察组在对照组基础上,采用龙生蛭胶囊治疗。采用美国国立卫生研究院卒中量表(NIHSS)评估患者的神经功能缺损程度。检测2组患者C反应蛋白(CRP)、同型半胱氨酸(Hcy)、基质金属蛋白酶-9(MMP-9)、细胞间黏附分子-1(ICAM-1)的水平。比较2组患者的神经功能指标[神经元特异性烯醇化酶(NSE)、S100-β蛋白、N端-脑钠肽前体(NT-proBNP)]的水平。运用脑卒中专用生活质量量表(SS-QOL)评估患者的生活质量。结果观察组的总有效率比对照组高,差异有统计学意义(P<0.05);2组治疗后的CRP、Hcy、MMP-9、ICAM-1明显降低(P<0.05);观察组治疗后的CRP、Hcy、MMP-9、ICAM-1比对照组低,差异有统计学意义(P<0.05)。2组治疗后的NSE、S100-β蛋白、NT-proBNP明显降低(P<0.05);观察组治疗后的NSE、S100-β蛋白、NT-proBNP比对照组低,差异有统计学意义(P<0.05)。2组治疗后的自理能力、活动能力、家庭角色、工作劳动、精力、上肢功能、总分明显升高(P<0.05);观察组治疗后的自理能力、活动能力、家庭角色、工作劳动、精力、上肢功能、总分比对照组高,差异有统计学意义(P<0.05)。结论龙生蛭胶囊可提高脑梗死的疗效,降低炎症因子的水平,减轻神经功能的损伤。
Objective To investigate the clinical efficacy of Longshengzhi capsule combined with butylphthalide in the treatment of cerebral infarction and its effect on serum inflammatory factors. Methods One hundred patients with cerebral infarction were divided into observation group and control group. The control group was treated with butylphthalide. The observation group was treated with Longshengzhi capsule on the basis of the control group. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the severity of neurological impairment. The levels of C-reactive protein (CRP), homocysteine (Hcy), matrix metalloproteinase-9 (MMP-9) and intercellular adhesion molecule-1 (ICAM-1) were measured in both groups. The levels of neurological function indexes [neuron specific enolase (NSE), S100-beta protein and N-terminal pro-brain natriuretic peptide (NT-pro BNP)] were compared between the two groups. The quality of life (QOL) of stroke patients was assessed by the Special Quality of Life Scale (SS-QOL). Results The total effective rate of the observation group was higher than that of the control group. The difference was significant (P<0.05). After treatment, CRP, Hcy, MMP-9 and ICAM-1 in both groups decreased significantly (P<0.05). After treatment, CRP, Hcy, MMP-9 and ICAM-1 in the observation group were lower than those in the control group. The difference was significant (P<0.05). After treatment, the levels of NSE, S100-beta protein and NT-pro BNP in both groups decreased significantly (P<0.05). After treatment, NSE, S100-beta protein and NT-pro BNP in the observation group were lower than those in the control group. The difference was significant (P<0.05). After treatment, the self-care ability, activity ability, family role, working, energy, upper limb function and total score of the two groups increased significantly (P<0.05). After treatment, the self-care ability, activity ability, family role, working, energy, upper limb function and total score of the observation group were higher than those of t
作者
卫家芬
徐雪明
邓小玲
常伟
Wei Jiafen;Xu Xueming;Deng Xiaoling;Chang wei(Waigang Town Health Center of Jiading District, Shanghai 201806, China)
出处
《山西医药杂志》
CAS
2019年第16期1954-1957,共4页
Shanxi Medical Journal
基金
上海市进一步加快中医药事业发展三年行动计划(2018—2020年)资助
上海市中医药特色示范社区卫生服务中心建设(2018—2020年)[ZY(2018-2020)-JCTS-1002-L19]
关键词
龙生蛭胶囊
丁苯酞
脑梗死
炎症趋化因子类
神经功能
Longshengzhi capsule
Butylphthalide
Cerebral infarction
Chemokines
Neurological function
