摘要
铁是人体内重要微量元素,过多或过少均会导致相应病理改变。目前虽无直接证据表明铁稳态破坏可导致神经退行性疾病发生,但已知铁含量异常参与多种疾病的发生过程。定量磁化率(QSM)成像具有高分辨率及高敏感性,可在大部分神经退行性疾病早期发现铁的异常沉积,近年已逐渐用于研究神经退行性疾病。本文针对QSM在阿尔茨海默病、帕金森病、杭廷顿病、多发性硬化以及肌萎缩脊髓侧索硬化症的脑内铁代谢研究进展进行综述。
Iron is an important trace element in human body, and too much or too little iron can lead to corresponding pathological changes. Although there is no direct evidence that the destruction of iron homeostasis leads to neurodegenerative diseases, it is undeniable that the abnormal iron content is involved in the pathogenesis of most diseases. Having high resolution and sensitivity, quantitative susceptibility mapping (QSM) imaging is able to detect abnormal iron depositions in the early stage of most neurodegenerative diseases, therefore it is used as the main method to quantitatively measure iron content in vivo brain tissue in the study of neurodegenerative diseases in recent years. QSM imaging research progresses of iron metabolism in Alzheimer disease, Parkinson disease, Huntington disease, multiple sclerosis and amyotrophic lateral sclerosis were reviewed in this article.
作者
李栋学
王頔
杨维新
熊真亮
宋辉
刘江勇
王荣品
LI Dongxue;WANG Di;YANG Weixin;XIONG Zhenliang;SONG Hui;LIU Jiangyong;WANG Rongpin(Department of Radiology, Guizhou Provincial People's Hospital, Key Laboratory of Intelligent Medical Imaging Analysis and Accurate Diagnosis of Guizhou Province,International Exemplary Cooperation Base of Precision Imaging forDiagnosis and Treatment, Guiyang 550002, China)
出处
《中国医学影像技术》
CSCD
北大核心
2019年第8期1248-1251,共4页
Chinese Journal of Medical Imaging Technology
基金
贵州省科技计划[黔科合支撑(2019)2810号]
黔科合平台人才计划[(2019)5803号
(2017)5724号]
关键词
神经变性疾病
定量磁化率成像
磁共振成像
neurodegenerative diseases
quantitative susceptibility mapping imaging
magnetic resonance imaging
