摘要
目的:探讨新疆维吾尔族人群非综合征型唇腭裂( NSCL/P)发病与环境因素的相关性。方法:纳入2014 ~ 2017 年的新疆维吾尔族NSCL/P 患者156 例,维吾尔族正常新生儿305 例,对患者的父母进行面对面问卷调查,用SPSS 22. 0 软件对数据进行Logistic 回归分析和χ^2 检验。结果:病例组中NSCL/P 患者唇裂∶唇裂合并腭裂∶腭裂比为= 1∶ 4. 63∶ 2∶ 58;多因素Logistic回归分析结果表明孕妇服用药物与NSCL/P 的关系为OR= 2. 53( 95% CI: 1. 29 - 10. 94),母亲家族史与NSCL/P 的关系为OR= 7. 29( 95%CI: 6. 84 - 23. 31),父亲家族史与NSCL/P 的关系为OR= 1. 43( 95% CI: 1. 89 - 4. 19);孕妇服用叶酸及维生素与NSCL/P 的关系为OR= 0. 36, 95%CI: 0. 19 - 0. 77,经济条件与NSCL/P 的关系为OR= 0. 13, 95%CI: 0. 25 - 0. 81。结论:母亲孕期服用药物、母亲家族史、父亲家族史是NSCL/P 的危险性因素,母亲孕期补充叶酸及维生素、经济条件是NSCL/P 的保护性因素。
Objective: To investigate the correlation between the incidence of non-syndromic cleft lip and palate( NSCL/P) and environmental factors in Xinjiang Uygur population. Methods: 156 NSCL/P patients and 305 normal newborns( the controls) from Xinjiang Uygur population in 2014 - 2017 were included. Participants’parents were subjected to a face-to-face questionnaire. SPSS 22. 0 software was used to manage the data by Logistic regression analysis and χ^2 test. Results: The types of NSCL/P were cleft lip∶ cleft lip and palate∶ cleft palate with the ratio of 1∶ 4. 63∶ 2∶ 58. Multivariate Logistic regression analysis showed that the relationship between the drug use of pregnant women with NSCL/P of their children was OR = 2. 53( 95%CI: 1. 29 - 10. 94),mother family history with NSCL/P OR = 7. 29( 95%CI: 6. 84 - 23. 31) and father family history with NSCL/P OR = 1. 43( 95% CI: 1. 89 - 4. 19);the relationship between pregnant women intaked folic acid or vitamin and NSCL/P was OR = 0. 36( 95%CI: 0. 19 - 0. 77),economic conditions and NSCL/P, OR = 0. 13( 95%CI: 0. 25 - 0. 81),respectively. Conclusion: Maternal drug use during pregnancy,maternal family history and paternal family history are risk factors for NSCL/P,maternal supplementation of folic acid or vitamins and economic conditions during pregnancy are the protective factors for NSCL/P.
作者
闫广鹏
李军
YAN Guangpeng;LI Jun(Department of Oral and Maxillofacial Surgery,People’s Hospital of Xinjiang Uyghur Autonomous Region,830001 Urumqi,China)
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2019年第4期529-533,共5页
Journal of Practical Stomatology
基金
新疆维吾尔自治区科学基金(编号:2016D01C098)
关键词
非综合征型唇腭裂(
NSCL
/P)
环境因素
维吾尔族
Non-syndromic cleft lip with or without cleft palate( NSCL /P)
Environmental factors
Uygur population
