摘要
目的研究探讨奥曲肽联合蛇毒血凝酶应用于治疗乙肝后肝硬化合并上消化道出血疾病时的临床疗效.方法选取2013年1月至2016年12月在我院感染科诊断并进行乙肝后肝硬化合并上消化道出血疾病的48例患者进行研究,按照随机分配的原则将48例患者均分成研究组和对照组,每组各24例患者,对照组24例患者采用传统的奥曲肽进行治疔,研究组在对照组的基础上联合使用蛇毒血凝酶进行治疗,经过治疗后,对比两组患者的临床止血效果.结果经过治疗后,研究组的止血时长为(17.9±4.3)h,对照组的止血时长为(28.2±4.1)h,对照组的止血时间显著长于研究组,差异具有统计学意义(P<0.05);研究组的止血成功率(87.50%)显著优于对照组的止血成功率(45.83%),P<0.05,差异具有统计学意义,研究组患者的再次出血率(8.33%)明显低于对照组的37.50%,表明研究组患者的止血疗效显著优于对照组,P<0.05,差异具有统计学意义;研究组的治疗后不良反应率(4.17%)明显低于对照组的(29.17%),P<0.05,差异具有统计学意义.结论在治疗乙肝后肝硬化合并上消化道出血时联合使用奥曲肽和血凝酶,明显有助于缩短止血时间,临床疗效显著,值得推广使用.
Objective To study the clinical efficacy of octreotide combined with snake venom hemocoagulase in the treatment of post-hepatitis B cirrhosis with upper gastrointestinal bleeding. Methods Forty-eight patients with post-hepatitis B cirrhosis complicated with upper gastrointestinal hemorrhage were selected from January 2013 to December 2016 in our hospital. According to the principle of random distribution, 48 patients were divided into study group and control group, 24 patients in each group. 24 patients in control group were treated with traditional octreotide. The study group was combined with snake venom on the basis of control group. Hemocoagulase treatment, after treatment, compared the two groups of patients with clinical hemostasis effect. Results After treatment, the duration of hemostasis in the study group was (17.9±4.3) h, and that in the control group was (28.2±4.1) h. The hemostasis time in the control group was significantly longer than that in the study group, with significant difference (P<0.05). The success rate of hemostasis in the study group (87.50%) was significantly better than that in the control group (45.83%), P<0.05. The difference was statistically significant. The re-bleeding rate of the study group (8.33%) was significantly lower than that of the control group (37.50%), indicating that the hemostatic effect of the study group was significantly better than that of the control group (P<0.05). The rate of adverse reactions after treatment in the study group (4.17%) was significantly lower than that in the control group (29.17%), P<0.05, with statistical significance. Conclusion The combination of octreotide and hemagglutinin in the treatment of post-hepatitis B cirrhosis with upper gastrointestinal hemorrhage can obviously shorten the hemostasis time, and the clinical effect is remarkable. It is worth popularizing.
作者
薛杰
XUE Jie(Suixi County Hospital, Suixi, Anhui 235100)
出处
《智慧健康》
2019年第19期48-49,55,共3页
Smart Healthcare
关键词
奥曲肽
蛇毒血凝酶
肝硬化合并上消化道出血
临床疗效
Octreotide
Snake venom enzyme
Liver cirrhosis complicated with upper gastrointestinal hemorrhage
Clinical efficacy
