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补肾调经方在IVF助孕出现卵巢低反应后应用的临床观察 被引量:6

Clinical Observation of Bushen Tiaojing Prescription after IVF Assisted Pregnancy with Ovarian Hyporesponsiveness
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摘要 目的评价补肾调经方对多次接受体外受精-胚胎移植(In Vitro Fertilization and Embryo Transfer,IVF-ET)后卵巢反应不良患者的干预作用。方法将60例卵巢低反应证属肾阴虚患者随机分为治疗组(补肾调经方),对照组(瓯佳侬),以1个月经周期为1疗程,连续服用3个疗程。比较2组患者的中医证候积分,临床疗效,卵泡刺激素(Follicule-Stimulating Hormone,FSH)、雌二醇(Estradiol,E2)、黄体生成素(Luteinizing hormone,LH)值及基础窦卵泡数目变化情况。结果(1)中医临床证候疗效:治疗组中医证候积分与对照组相比均明显降低,差异有统计学意义(P<0.01),中医证候(肾阴虚证)治疗总有效率与对照组相比明显升高,差异有统计学意义(P<0.01)。(2)基础性激素水平:与治疗前相比,治疗组能明显降低升高的FSH值(P<0.01);对E2有双向调节作用,能降低过高的E2,升高过低的E2(P<0.01);LH水平治疗前后差异无统计学意义(P>0.05)。对照组能明显降低升高的FSH(P<0.01)及LH(P<0.01);而E2在治疗前后无显著变化(P>0.05)。与对照组相比,治疗组对降低升高的FSH的效果比对照组更显著,差异有统计学意义(P<0.01)。(3)基础窦卵泡数目:2组均能增加基础窦卵泡偏少的数目,差异无统计学意义(P>0.05)。结论补肾调经方可有效减轻卵巢低反应证属肾阴虚患者中医相关证候,降低过高的FSH水平,对E2具有双向调节作用,对基础窦卵泡的数目偏少的患者可有效增加其窦卵泡数目,值得临床推广与应用。 Objective: To evaluate the intervention effect of Bushen Tiaojing Prescription on patients with ovarian dysfunction after multiple in vitro fertilization-embryo transfer(IVF-ET). Methods: 60 ovarian dysfunction patients with kidney yin deficiency were randomly divided into a treatment group(Bianshen Tiaojing) and a control group(Oujianong), and given these medicine one menstrual circle for a course of treatment for 3 courses continuously. The TCM syndrome scores, clinical effect, follicule-stimulating hormone(FSH), estradiol(E2), luteinizing hormone(LH) value and changes in the number of basal sinus follicles happening of the two groups were compared. Results:(1) Clinical syndrome effect of TCM: The TCM syndrome scores of the treatment group were significantly lower than those of the control group, and the difference was statistically significant(P<0.01), and the total effective rate of TCM syndrome(kidney yin deficiency) treatment was higher when compared with that of the control group, and the difference was statistically significant(P<0.01).(2) Basic hormone levels: Compared with the prior treatment, the elevated FSH value in the treatment group significantly reduced(P<0.01). It had a two-way regulation effect on E2, which can reduce the excessively high E2 and increase the excessively low E2(P<0.01). There was no significant difference in LH level before and after treatment(P>0.05). The elevated FSH(P<0.01) and LH(P<0.01) in the control group significantly decreased while E2 did not change significantly before and after treatment(P>0.05). Compared with the control group, the effect of the treatment group on the reduction of the elevated FSH was more significant than that of the control group, and the difference was statistically significant(P<0.01).(3) Number of basal sinus follicles: Both groups could increase the number of underlying antral follicles, and the difference was not statistically significant(P>0.05). Conclusion: Bushen Tiaojing Prescription can effectively alleviate TCM-related syndromes in pati
作者 张亚嘉 李钦 王堉如 陈冬琼 ZHANG Ya -jia;LI Qin;WANG Yi-ru;CHEN Dong-qiong(Yunnan Provincial Hospital of Traditional Chinese Medicine,Kunming650021,China;Yunnan Institute of Traditional Chinese Medicine and Materia Medica,Kunming 650223,China)
出处 《云南中医中药杂志》 2019年第7期16-21,共6页 Yunnan Journal of Traditional Chinese Medicine and Materia Medica
基金 云南省医疗卫生单位内设研究机构科研项目(2014NS304)
关键词 体外受精-胚胎移植 卵巢反应不良 补肾调经方 临床疗效 in vitro fertilization-embryo transfer ovarian dysfunction Bushen Tiaojing prescription clinical effect
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