摘要
脊柱韧带骨化是临床较常见的一类与多种因素相关且病因不明的疾病,其病理生理机制主要是正常韧带纤维组织转变成骨性组织且不断增生。脊柱韧带骨化是一种脊柱韧带异位骨化症,将导致椎管管径变窄,继发不同程度的脊髓和神经根压迫,造成脊髓神经功能损害,主要包括后纵韧带骨化和黄韧带骨化。对于脊柱韧带骨化病,手术干预是目前仅有的有效治疗措施,但手术疗效并不十分满意。因此了解脊柱韧带骨化病的病因及发病机制,对韧带骨化病的预防和治疗具有重要的临床意义。脊柱韧带骨化发病机制复杂,理想的动物模型对研究其病因、发病机制等具有十分重要的意义。对近年来关于脊柱韧带骨化多种动物模型制备方法进行综述,为今后相关实验的动物模型选择提供参考。
Ossification of spinal ligament (OSL) is a common clinical disease associated with many factors while its etiology is unknown. It is characterized by heterotopic ossification of spinal ligament, which leaded to narrowing of spinal canal diameter, followed by spinal cord and nerve root lesions in varying degrees, including ossification of posterior longitudinal ligament (OPLL) and ossification of flavum ligament (OLF). At present, surgical intervention of ossification of spinal ligament is the only effective treatment method, while the clinical effect is not very satisfactory. Therefore, understanding the etiology and pathogenesis of the ossification of the spinal ligament has important clinical significance for the prevention and treatment of ossification of the ligament. The pathogenesis of ossification of spinal ligament is complex. An ideal animal model is of great significance in studying its etiology and pathogenesis. In this paper, the modeling methods of various animal models of spinal ligament ossification in recent years were reviewed, which could provide reference for the selection of animal models for future experiments.
作者
许国峰
陈雄生
Xu Guofeng;Chen Xiongsheng(Department of Spine Surgery, Changzheng Hospital, Naval Military Medical University, Shanghai 200003, China)
出处
《中华骨科杂志》
CAS
CSCD
北大核心
2019年第14期897-901,共5页
Chinese Journal of Orthopaedics
