摘要
目的探讨前列地尔联合依达拉奉对老年脑梗死患者血液流变学及神经功能的影响。方法老年脑梗死患者124例,采用随机数字表法将患者分为对照组和研究组,每组62例。对照组采用前列地尔治疗,研究组采用前列地尔联合依达拉奉治疗。比较2组临床疗效、血液流变学指标[红细胞压机(HCT)、全血低切黏度、全血高切黏度、血浆黏度、血小板聚集率(PAR)、纤维蛋白原(Fib)]、神经功能[神经功能缺损程度评分(HIHSS)]和药物不良反应的差异。结果研究组治疗总有效率明显高于对照组,(P<0.05)。治疗前,2组HCT、全血低切黏度、全血高切黏度、血浆黏度、PAR、Fib水平比较差异无统计学意义(P>0.05),治疗后,2组上述指标均呈不同程度的降低倾向,治疗前后比较差异有统计学意义(P<0.05),其中研究组上述指标的降低幅度较对照组更明显,2组比较差异有统计学意义(P<0.05)。治疗前,2组NIHSS评分比较差异无统计学意义(P>0.05),治疗后,2组NIHSS评分明显低于治疗前,(P<0.05),且研究组NIHSS评分较对照组降低更明显,(P<0.05)。2组药物不良反应发生率比较差异无统计学意义(P>0.05)。结论前列地尔联合依达拉奉可有效安全应用于老年脑梗死患者的治疗中,有利于明显改善血液流变学及神经功能,值得临床推广应用。
Objective To explore the effects alprostadil combined with edaravone on hemorheological indexes and neurological function of elderly patients with cerebral infarction.Methods A total of 124 elderly patients with cerebral infarction who were admitted and treated in our hospital from January 2015 to January 2018 were enrolled in the study,who were divided into control group and research group,with 62 cases in each group.The patients in control group were treated by alprostadil,however,the patients in research group,on the basis of control group,were treated by edaravone.The clinical curative effects,hemorheological indexes,neurological function and adverse drug reactions were observed and compared between the two groups.Results The total effective rate in research group was significantly higher than that in control group(P<0.05).Before treatment,there were no significant differences in the levels of HCT,whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity,PAR,Fib between the two groups(P>0.05).After treatment,the above indexes in both groups were decreased at different extents,there were significant differences before treatment and after treatment(P<0.05),moreover,which in research group were significantly lower than those in control group(P<0.05).Before treatment,there were no significant differences in NIHSS scores between the two groups(P>0.05).After treatment,the NIHSS scores in both groups were significantly lower than those before treatment(P<0.05),moreover,which in research group were significantly lower than those in control group(P<0.05).In addition there was no significant difference in the incidence rate of adverse drug reactions between the two groups(P>0.05).Conclusion Alprostadil combined edaravone can be effectively and safely applied in treatment of cerebral infarction in elderly patients,which is beneficial to obviously improve hemorheological indexes and neurological function of patients,therefor,it is worthy of clinical application and promotion.
作者
闵榴芳
MIN Liufang(Emergency Department,Chang’an Hospital of Xi’an City,Shaanxi,Xi’an 710016,China)
出处
《河北医药》
CAS
2019年第16期2490-2493,共4页
Hebei Medical Journal
关键词
前列地尔
依达拉奉
老年
脑梗死
血液流变学
神经功能
alprostadil
edaravone
the elderly
cerebral infarction
hemorheology
neurological function
