摘要
目的探讨肺癌合并马尔尼菲蓝状菌病的临床特点、肺部影像学表现和病理改变,提高对该病的认识。方法回顾性分析并总结深圳市人民医院2018年9月21日收治的肺癌合并马尔尼菲蓝状菌病患者1例,收集其临床资料,分析诊治过程,并检索近年来国内外主要文献进行复习。结果非HIV患者男,52岁,以咳嗽、咳痰、呼吸困难和消瘦等为主要临床表现,痰培养提示马尔尼菲蓝状菌,右上肺结节病理提示肺腺癌。结论HIV阴性免疫受损人群是马尔尼菲蓝状菌病高危人群,临床表现缺乏特征性,可引起多脏器损害,易误诊,对于有流行区生活史的患者及免疫受损者,应警惕是否为马尔尼菲蓝状菌感染,尽早确诊并治疗。
Objective To analyze the clinical recognition of talaromyces marneffei infection complications in an HIV-negative patient with lung cancer in clinical manifestations,diagnosis and treatment.Methods The clinical manifestations,pathological characteristic,imaging manifestations,diagnosis,the therapy and review of literature of a patient with talaromyces marneffei infection complications in an HIV-negative patient with lung cancer were presented.Results The HIV-negative patient was a 52-year-old male,with cough,expectoration,dyspnea and wasting as the main symptom.Themicrobes of sputum culture were Talaromyces marneffei.The pulmonary nodule in the right upper lobe was pathologically confirmed as lung adenocarcinoma.Combined with the clinical symptoms,the patient was diagnosed as lung adenocarcinoma with Talaromycosis marneffei.Conclusion Patients with non-HIV immunocompromised are high-risk groups of Marneffeinosis,which are clinically lack of characteristics.It can cause multiple organ damages and is easy to be misdiagnosed.For patients with life history in epidemic areas or immunocompromised patients,they should be alert to whether it is Talaromyces marneffei infection and make diagnosis and treatment as soon as possible.
作者
杨蓬
刘萍
李秋文
卢月梅
王凌伟
YANG Peng;LIU Ping;LI Qiu-wen;LU Yue-mei;WANG Ling-wei(Shenzhen People's Hospital,Shenzhen Institute of Respiratory Disease,The First Affiliated Hospital of Southern University of Science and Technology,The Second Clinical Medical College of Jinan University,Shenzhen Institute of Respiratory Diseases,Guangdong Shenzhen 518020,China)
出处
《新发传染病电子杂志》
2019年第3期169-172,共4页
Electronic Journal of Emerging Infectious Diseases
基金
深圳市卫生计生系统科研项目(SZLY2017024)
