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丹参川芎嗪注射液对急性血瘀模型大鼠血液流变学及血浆中GMP-140、vWF的影响 被引量:9

Effect of Danshen Chuangxiongqin injection on hemorheology and plasma GMP-140 and vWF in acute blood stasis model rats
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摘要 目的研究丹参川芎嗪注射液对急性血瘀模型大鼠血液流变学及血浆中α颗粒膜蛋白(GMP-140)、血管性血友病因子(vWF)的影响。方法采用皮下注射肾上腺素复加冰水浴的方法,复制急性血瘀模型大鼠,观察丹参川芎嗪注射液对急性血瘀模型大鼠血液流变学及血浆中GMP-140、vWF的影响。结果与模型组相比,丹参川芎嗪注射液能够明显降低急性血瘀模型大鼠的全血低、中、高切黏度及血浆黏度,减少模型大鼠血液中GMP-140、vWF的含量。结论丹参川芎嗪注射液能够明显改善急性血瘀模型大鼠血液流变学指标,这可能与其下调血浆中GMP-140、vWF的含量有关。 Objective To determine the effect of Danshen Chuangxiongqin injection on hemorheology and plasmaα-granule membrane protein(GMP-140)and von Willebrand factors(vWF)in acute blood stasis model rats.Methods The rats with acute blood stasis were replicated by subcutaneous injection of adrenaline plus ice water bath.The effect of Danshen Chuangxiongqin injection on hemorheology and plasma GMP-140 protein and vWF factors in acute blood stasis model rats were observed.Results Compared with the model group,Danshen Chuangxiongqin injection significantly reduced the low,medium and high viscosity and plasma viscosity of whole blood in rats with acute blood stasis,and reduced the content of GMP-140 protein and vWF factor in the blood of model rats.Conclusion Danshen Chuangxiongqin injection significantly improves the hemorheology of acute blood stasis model rats,which may be related to the down-regulation of GMP-140 protein and vWF factors in the plasma.
作者 董庆海 刘慧 王涵 吴福林 谭静 刘金平 李平亚 DONG Qing-hai;LIU Hui;WANG Han;WU Fu-lin;TAN Jing;LIU Jin-ping;LI Ping-ya(NaturalProduct Research Center,College of Pharmacy,Jilin University,Changchun 130021;Jilin SichangPharmaceutical Co.,Ltd.,Meihekou Jilin 135000)
出处 《中南药学》 CAS 2019年第7期1044-1046,共3页 Central South Pharmacy
基金 吉林省省校共建计划专项(No.SXGLSF2017-1-1) 吉林省科技发展计划项目(No.20180004)
关键词 丹参川芎嗪注射液 急性血瘀模型 血液流变学 Α颗粒膜蛋白 血管性血友病因子 Danshen Chuangxiongqin injection acute blood stasis model hemorheology α-granule membrane protein von Willebrand factor
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