摘要
随着精准医疗在肿瘤领域中的发展,得益于各种最新的筛查技术,对肿瘤进行实时监测的要求越来越高。传统的组织活检由于穿刺的临床风险、肿瘤异质性等问题,不宜反复进行;超声、内镜等影像学检查主观性较强,很难检测到微小病灶,越来越无法满足实时监测的要求。而循环肿瘤DNA以其标本获取简便、创伤小、可重复性、实时监测疗效等优势,在肿瘤诊疗方面具有重要应用前景。本文结合国内外最新报道,对循环肿瘤DNA在食管癌的早期诊断、治疗及预后方面的研究进展进行综述。
With the development of precision medicine in the field of tumor, thanks to the latest screening technology, the demand for real-time monitoring of tumor is increasingly high. Traditional tissue biopsy is not suitable for repeated due to clinical problems such as puncture clinical risk and tumor heterogeneity. Ultrasound, endoscopy and other imaging examinations are highly subjective, and it is difficult to detect small lesions, and increasingly unable to meet the requirements of real-time monitoring. However, circulating tumor DNA, with its advantages of simple sample acquisition, small trauma, repeatability and real-time monitoring efficacy, has an important application prospect in tumor diagnosis and treatment. Based on the latest reports at home and abroad, this paper reviews the research progress of circulating tumor DNA in the early diagnosis, treatment and prognosis of esophageal cancer.
作者
吴斌
王志豪
马骏
史宏灿
Wu Bin;Wang Zhihao;Ma Jun;Shi Hongcan(Department of Thoracic and Cardiac Surgery,Clinical Medicine College of Yangzhou University,Yangzhou 225001,China)
出处
《国际外科学杂志》
2019年第7期491-495,共5页
International Journal of Surgery
基金
扬州大学“高端人才支持计划”资助(201431).
关键词
食管肿瘤
DNA
肿瘤
诊断
Esophageal neoplasms
DNA, neoplasm
Diagnosis
