摘要
战创伤导致急性肾损伤(AKI)的机制非常复杂,其中以脓毒症相关AKI危害最大、处理最为困难。尽管医学界非常重视该疾病,致力于从其发病机制、生物标志物和早期诊断思路、规范化治疗等方面提高对疾病的认识和治疗水平,在脓毒症相关AKI的分级、抗感染、液体复苏,以及肾脏替代治疗方面取得了一些共识,也发表了一系列文献和指南,使患者生存状况得到一定提升,但仍有很多基础和临床上的问题还存在争议,需要进一步的研究。该文聚焦于脓毒症相关AKI的发病机制、诊断及治疗进展,以期提高临床医师对脓毒症相关AKI早期诊断及规范化治疗的认识水平。
The mechanisms of traumatic injury-induced acute kidney injury(AKI) are very complicated.Among these mechanisms,sepsis-related AKI is the most harmful and the most difficult to treat.The medical community gave a high priority on this disease,dedicated to raise the level of awareness and treatment through its pathogenesis,early diagnosis ideas and biomarkers,and standardization of treatment.There has been some consensus on the classification of sepsis,AKI,and treatments of antiinfection,fluid resuscitation,renal replacement therapy.A series articles and guidelines have also been published and the survival status of patients have been improved,but many basic and clinical issues are still controversial and need to be answered by further trails.This article focuses on the progress of pathogenesis,diagnosis and treatment about sepsis-related AKI,and tries to raise the understanding level of early diagnosis and standardized treatment of it.
作者
李冀军
陈凤锟
姚凤华
LI Ji-jun;CHEN Feng-kun;YAO Feng-hua(Department of Nephrology, the Fourth Medical Center of Chinese PLA General Hospital, Beijing 100048, China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2019年第7期561-567,共7页
Medical Journal of Chinese People's Liberation Army
基金
首都卫生发展科研专项课题(首发2011-5002-04)~~
关键词
脓毒症
急性肾损伤
战创伤
sepsis
acute kidney injury
traumatic injury
