摘要
目的观察拉莫三嗪添加-替换在丙戊酸治疗无效的癫痫患者的效果。方法选择2016年1月—2018年2月期间该院收治的68例丙戊酸治疗无效的癫病患者,随机分为对照组(采用拉莫三嗪替换治疗)和观察组(采用拉莫三嗪添加治疗),各34例,对比两组临床疗效、治疗结束后3个月癫痫发作频率,并监测两组不良反应情况。结果治疗结束后3个月,观察组疗效优于对照组(P<0.05);观察组1个月内癫痫发作次数(2.18±1.02)次显著低于对照组(3.32±1.24)次,差异有统计学意义(t=13.158,P=0.018)。对照组出现2例震颤、1例嗜睡、1例胃肠道反应、1例转氨酶升高,不良反应发生率为14.71%(5/34);观察组出现3例震颤、1例嗜睡、1例胃肠道反应、2例转氨酶升高,不良反应发生率为20.59%(7/34)。两组差异无统计学意义(χ^2=0.798,P=0.829)。结论丙戊酸治疗无效患者采用拉莫三嗪添加治疗,疗效优于其替换治疗,临床应用安全可靠。
Objective To observe the effect of lamotrigine addition-substitution in the treatment of epilepsy patients with valproic acid ineffective.Methods Sixty-eight patients with epilepsy who failed to respond to valproic acid treatment from January 2016 to February 2018 were randomly divided into control group(treated with lamotrigine replacement therapy)and observation group(treated with lamotrigine addition therapy),34 cases in each group.The clinical efficacy and seizure frequency of epilepsy in the two groups were compared after 3 months of treatment,and adverse reactions in the two groups were monitored.Result 3 months after the end of treatment,the curative effect of the observation group was better than that of the control group(P<0.05);the number of epileptic seizures in the observation group(2.18±1.02)times in one month was significantly lower than that of the control group(3.32±1.24)times,the difference was statistically significant(t=13.158,P=0.018).There were 2 tremors,1 sleepiness,1 gastrointestinal reaction and 1 elevated transaminase in the control group,and the incidence of adverse reactions was 14.71%(5/34).In the observation group,there were 3 tremors,1 sleepiness,1 gastrointestinal reaction and 2 elevated transaminase.The incidence of adverse reactions was 20.59%(7/34).There was no significant difference between the two groups(χ^2=0.798,P=0.829).Conclusion The effect of lamotrigine is better than its replacement therapy in the treatment of invalid patients with valproic acid,and its clinical application is safe and reliable.
作者
孟祥君
郅颖
MENG Xiang-jun;ZHI Ying(Department of Neurology,First Affiliated Hospital,Baotou Medical College,Inner Mongolia University ofScience and Technology,Baotou ,Inner Mongolia,014010 China;Department of Laboratory,FirstAffiliated Hospital,Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou ,Inner Mongolia,014010 China)
出处
《系统医学》
2019年第11期52-54,共3页
Systems Medicine
关键词
拉莫三嗪
添加
替换
丙戊酸
治疗无效
癫痫患者
效果
Lamotrigine
Addition
Replacement
Valproic acid
Treatment ineffective
Epilepsy patients
Effect
