摘要
目的探究老年重症心力衰竭患者在急诊内科采用美托洛尔与厄贝沙坦氢氯噻嗪联合治疗效果。方法选择2016年12月至2017年12月本院急诊内科收治的重症心力衰竭患者78例,采用随机数字表法将其分为实验组与参照组,每组39例。其中参照组采用美托洛尔治疗,实验组行美托洛尔与厄贝沙坦氢氯噻嗪联合治疗,对比两组患者治疗后生活质量评分、治疗前后血清脑钠肽及临床治疗效果。结果治疗前,两组血清脑钠肽差异无统计学意义,经治疗两组患者血清脑钠肽均有所下降,实验组治疗后血清脑钠肽水平明显低于参照组(P<0.05);实验组睡眠质量、精神状态、心理情绪、自理能力评分均高于参照组,与参照组相比,实验组疼痛评分较低(P<0.05);实验组临床治疗总有效率为94.87%,明显优于参照组(74.36%),两组差异具有统计学意义(P<0.05)。结论联合应用美托洛尔与厄贝沙坦氢氯噻嗪药物的临床疗效显著,能够提升患者心功能,从而改善老年重症心力衰竭患者临床症状,应予以临床推广。
Objective To investigate the effect of metoprolol combined with irbesartan hydrochlorothiazide in the treatment of elderly patients with severe heart failure. Methods 78 patients with severe heart failure who were treated in the emergency department of our hospital were enrolled. The patients were enrolled from December 2016 to December 2017. They were divided into experimental group and reference group by random number table, with 39 cases in each group. The reference group was treated with metoprolol. The experimental group was treated with metoprolol and irbesartan hydrochlorothiazide. The quality of life scores, serum brain natriuretic peptide and clinical therapeutic effects were compared between the two groups. Results There was no significant difference in serum brain natriuretic peptide between the two groups before treatment. The serum brain natriuretic peptide levels in the two groups were decreased after treatment, but the serum brain natriuretic peptide level in the experimental group was significantly lower than that in the reference group (P<0.05). The scores of sleep quality, mental state, psychological mood and self-care ability were higher than the reference group. Compared with the reference group, the pain score of the experimental group was lower. The total effective rate of clinical treatment in the experimental group was 94.87%, which was significantly better than the reference group (74.36%), the difference between the two groups was statistically significant (P<0.05). Conclusion The combined clinical application of metoprolol and irbesartan hydrochlorothiazide has a significant clinical effect, which can improve the heart function of patients and improve the clinical symptoms of elderly patients with severe heart failure, it should be clinically promoted.
作者
李辉
赵珍珍
武文成
Li Hui;Zhao Zhenzhen;Wu Wencheng(Department of Emergency,Feicheng People' s Hospital of Shandong Province,Feicheng,Shandong,250002,China;Department of Cardiology,Feicheng People' s Hospital of Shandong Province,Feicheng,Shandong,250002,China)
出处
《当代医学》
2019年第21期26-28,共3页
Contemporary Medicine
关键词
美托洛尔
厄贝沙坦氢氯噻嗪
老年
重症心力衰竭
急诊内科
Metoprolol
Irbesartan hydrochlorothiazide
Elderly
Severe heart failure
Department of emergency internal medicine
