摘要
目的探讨胰腺神经内分泌肿瘤(PNEN)的临床及病理特征。方法收集8例PNEN的临床及病理资料,依据WHO(2017)内分泌肿瘤的新分级标准重新分级,分析其临床病理特征、治疗及预后。结果 8例中男4例,女4例,中位年龄45岁;肿瘤最大径1.5~10.0cm,中位数6.0cm。胰腺神经内分泌瘤(PNET)G1级2例、G2级4例,胰腺神经内分泌癌(PNEC)2例,无PNET G3级病例。显微镜下示肿瘤多由小圆细胞构成,排列呈假菊形团状、梁索状、实体性。免疫组织化学示7例CgA阳性,6例Syn阳性,1例PNET G2级ATRX阴性,1例PNEC TP53阳性。本组7例获得随访,随访时间10个月至4年,4例出现肝转移,其中1例伴有腹腔转移。结论 PNEN是一类罕见的肿瘤,多无典型症状,确诊主要依据其病理形态特征和免疫组织化学表型。
Objective To investigate the clinical and pathological features of pancreatic neuroendocrine neoplasms(PNEN).Methods The clinical and pathological data in 8 cases of PNEN were collected and reclassified based on WHO(2017)new classification criteria for endocrine neoplasms to analyze its clinicopathologic features,therapies and prognoses.Results Among 8 cases,there were 4 males and 4 females,and the median age was 45 years old.The maximum diameter of the neoplasm ranged from 1.5-10.0 cm(average 6.0 cm).There were 2 cases of pancreatic neuroendocrine carcinoma tumor(PNET)G1,4 cases of G2,2 cases of pancreatic neuroendocrine carcinoma(PNEC),and no cases of PNET G3.Under the microscope,the neoplasms were mostly composed of small round cells and arranged in pseudorosette,trabecular,and solid architecture.The immunohistochemistry showed that 7 cases were positive for CgA,6 cases were positive for Syn,1 case of PNET G2 was negative for ATRX,and 1 case of PNEC was positive for TP53.Seven patients in this group were followed up for 10 months to 4 years.Liver metastases occurred in 4 cases,and 1 case was accompanied by celiac metastasis.Conclusion PNEN is a kind of rare neoplasms without typical symptoms.The diagnosis is based on their pathological features and immunohistochemical phenotype.
作者
刘云
郭庆喜
卢子剑
冯健
石敏
刘祖平
孙兴旺
LIU Yun;GUO Qingxi;LU Zijian;FENG Jian;SHI Min;LIU Zuping;SUN Xingwang(College of Basic Medicine Southwestern Medical University,Luzhou, Sichuan 646000,China;Department of Pathology,Affiliated Hospital of Southwest Medical University,Luzhou, Sichuan 646000,China;Department of Cardiology, Affiliated Hospital of Southivest Medical University,Luzhou,Sichuan 646000)
出处
《重庆医学》
CAS
2019年第13期2206-2209,2216,共5页
Chongqing medicine
基金
国家自然科学基金项目(31300946)
四川省科技厅项目(14JC0084)
泸州市人民政府-西南医科大学科技战略合作项目(2017LZXNYD-P02)
关键词
神经内分泌瘤
胰腺肿瘤
病理特征
组织学分级
免疫组织化学
neuroendocrine tumors
pancreatic neoplasms
pathological features
histological grade
immunohistochemistry
