摘要
目的观察接受规律治疗的假性甲状旁腺功能减退症(pseudohypoparathyroidism, PHP)患者的生活质量(quality of life)及肌肉力量(肌力)的情况。方法纳入2017年7月至2018年7月间于北京协和医院随访的PHP患者23例,按性别年龄1比1匹配非术后甲状旁腺功能减退症(nonsurgical hypoparathyroidism, nHPT)患者23例及健康对照人群23名。采用SF36v2量表(Short Form 36 Health Survey questionnaire version 2)评价生活质量,通过测量握力及重复坐下站起(repeated chair stand, RCS)试验分别评估上下肢肌力。结果PHP患者除生理功能(physical functioning)一项外,SF36v2量表中其余各项得分均较健康对照组降低(P<0.05)。与nHPT组相比,PHP患者仅在社会功能(social functioning)一项上得分较高,其余各项差异无统计学意义。另外,PHP患者握力与RCS时间均与健康对照组相似。结论PHP患者经过规律治疗后,生活质量评分仍低于健康对照,本组研究未发现PHP患者上下肢肌力较健康对照组有明显差异。
Objective To explore the quality of life (QoL) and muscle strength in patients with pseudohypoparathyroidism (PHP) under regular treatment. Methods Twenty-three patients with PHP regularly followed at Peking Union Medical College Hospital from June 2017 to June 2018 were included. Age- and gender-matched 23 patients with nonsurgical hypoparathyroidism (nHPT) and 23 healthy controls were also included. Short Form 36 Health Survey questionnaire version 2 (SF36v2) were used to evaluate the QoL. Grip strength and repeated chair stand (RCS) were used to assess muscle strength for upper and lower limbs respectively. Results Except for physical functioning, patients of PHP group had reduced scores in all other subdomains of SF36v2 compared to healthy controls (P<0.05). Comparing to nHPT patients, PHP patients had a higher score in social functioning, while no difference was found in other subdomains of SF36v2. Grip strength and RCS tests were similar in PHP patients and healthy controls. Conclusions Comparing to healthy controls, patients with PHP still had impaired QoL despite regular management, no significant difference of upper and lower limb muscle strength was found between PHP group and healthy controls.
作者
陈思行
王亚冰
王鸥
聂敏
姜艳
李梅
夏维波
邢小平
Chen Sixing;Wang Yabing;Wang Ou;Nie Min;Jiang Yan;Li Mei;Xia Weibo;Xing Xiaoping(Key Laboratory of Endocrinology of Health Ministry of China, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2019年第6期480-485,共6页
Chinese Journal of Endocrinology and Metabolism
