摘要
目的探讨儿童过敏性紫癜与幽门螺旋杆菌感染的关系,分析过敏性紫癜患儿合并幽门螺旋杆菌感染的危险因素。方法 2016年1月-2017年12月在本院诊断为过敏性紫癜患儿164例,其中腹型过敏性紫癜组78例,非腹型过敏性紫癜组86例,采用13C尿素呼气试验法检测幽门螺旋杆菌感染率。对过敏性紫癜合并幽门螺旋杆菌感染的相关危险因素进行多因素Logistic回归分析。结果 78例腹型过敏性紫癜患儿有37例13C尿素呼气试验阳性,阳性率为47.44%;86例非腹型过敏性紫癜患儿有19例13C尿素呼气试验阳性,阳性率为22.09%,2组差异有统计学意义(P=0.001)。多因素Logistic回归提示"消化道出血"是过敏性紫癜合并HP感染的危险因素(OR:1.050~17.202,P=0.043)。结论"消化道出血"是儿童过敏性紫癜合并HP感染的危险因素。对于过敏性紫癜合并有消化道出血症状或者反复腹痛持续时间长、有胃炎家族史的患儿,建议筛查是否幽门螺旋杆菌感染。
Objective To investigate the relationship between Henoch-Sch?nlein purpura(HSP) in children and Helicobacter pylori(HP) infection,and to analyze the risk factors of HP infection in children with HSP.Methods 164 cases of HSP,including 78 cases with abdominal symptoms and 86 cases without abdominal symptoms,were diagnosed from January 2016 to December 2017.The infection rate of HP was detected by 13C urea breath test(13C-UBT).Multivariate Logistic regression analysis was performed on the risk factors of HSP with HP infection.Results 37 cases of 13C-UBT in 78 HSP patients with abdominal symptoms were positive(47.44%),while 19 cases were detected in 86 patients without abdominal symptoms(22.09%),and the difference was statistically significant(P=0.001).Multivariate Logistic regression suggested that gastrointestinal bleeding was a risk factor for HSP with HP infection(OR: 1.050-17.202,P=0.043).Conclusion Gastrointestinal bleeding is a risk factor for HSP patients with HP infection.HSP patients with gastrointestinal bleeding or recurrent abdominal pain or family history of gastritis are recommended to undergo HP screening.
作者
任晓碧
吴素素
谢敏叶
杨建环
REN Xiao-bi;WU Su-su;XIE Min-ye;YANG Jian-huan(Pediatric Nephrology,Yuying Children's Hospital,the Second Hospital Affiliated to Wenzhou Medical University,Wenzhou,Zhejiang 325027,China)
出处
《中国卫生检验杂志》
CAS
2019年第13期1589-1590,1594,共3页
Chinese Journal of Health Laboratory Technology
关键词
幽门螺旋杆菌
过敏性紫癜
呼气试验
Helicobacter pylori
Henoch-Schonlein purpura
Breath test
