摘要
目的 探讨四联止吐方案在预防高度致吐性化疗所致恶心呕吐中的应用。方法 选取2017年7月-2018年9月我院收治的53例卵巢癌、乳腺癌和肺癌患者,采用随机数字表法分为观察组(26例)和对照组(27例)。入组患者均接受含顺铂或表阿霉素的高度致吐性化疗方案,对照组采用托烷司琼+地塞米松常规止吐方案,观察组采用阿瑞匹坦+奥氮平+托烷司琼+地塞米松四联止吐方案。比较两组患者恶心、呕吐的预防有效率,采用呕吐生活功能指数(FLIE)评价两组患者的生活质量,并比较两组患者的不良反应发生率。结果 观察组和对照组恶心的预防有效率分别为88.5%和62.9%,差异有统计学意义(P<0.05);观察组和对照组急性呕吐和延迟性呕吐的预防有效率分别为84.6%、59.3%和80.7%、51.9%,差异均有统计学意义(P<0.05);观察组和对照组FLIE评分分别为(85.27±8.54)和(72.18±7.98),差异有统计学意义(P<0.01);不良反应方面,观察组患者呃逆及嗜睡的发生率显著高于对照组(P<0.05),其他不良反应两组间无明显差异(P>0.05)。结论 四联止吐方案可显著提高接受高度致吐性化疗方案的患者恶心、呕吐的预防效果,有助于改善患者的生活质量。
Objective To explore the application of four antiemetic regimens (aprepitant, olanzapine, tropisetron and dexamethasone in combination) in preventing nausea and vomiting caused by highly emetic chemotherapy. Methods Fifty-three patients of ovarian cancer, breast cancer and lung cancer selected beteween July 2017 and September 2018 were randomly divided into observation group (n=26) and control group (n=27). All patients received highly emetogenic chemothrapy such as cisplatin or epirubicin. Patients in control group got tropisetron combined dexamethasone, while those in observation group received aprepitant + olanzapine + tropisetron + dexamethasone. Compare the incidence of acute, delayed nausea and vomiting. Functional living index-emesis (FLIE) was applied to assess the quality of life of patients. The adverse reactions were also compared. Results The cause control rate was 88.5% and 62.9% respectively in the observation group and control group (P<0.05). The complete remission of acute vomiting was respectively 84.6% and 59.3% in the observation group and control group (P<0.05). The complete remission of delayed vomiting in observation and control group was respectively 80.7% and 51.9%(P<0.05). The FLIE of observation group and control group were respectively (85.27±8.54) and (72.18±7.98)(P<0.01). The incidence of somnolence and singultation were higher in the observation group than in the control group (P<0.05). There were no significant differences between the two groups in the other adverse effects (P>0.05). Conclusion The quadruple antiemetic regimen could improve the control rate of acute and delayed nausea and vomiting induced by highly emetogenic chemotherapy, and improve the quality of life.
作者
仲飞
秦学金
刘婧婧
韩柯
康慢慢
ZHONG Fei;QIN Xuejin;LIU Jingjing;HAN Ke;KANG Manman(Department of Oncology, Fuyang Hospital of Anhui Medical University, Fuyang, Anhui, 236000, China)
出处
《肿瘤药学》
CAS
2019年第3期475-478,489,共5页
Anti-Tumor Pharmacy
基金
中国博士后科学基金面上项目(2016M590560)
