摘要
肌松药的发现和应用引发了现代麻醉技术的重大变革,并促进了老年外科、心脏外科和移植外科学的迅猛发展。但使用肌松药可能伴随的肌松残留风险会严重影响手术预后。传统肌松拮抗药--胆碱酯酶抑制剂新斯的明存在明显的作用局限性,不能满足临床需求。新型肌松药拮抗剂舒更葡糖钠可精准、快速地逆转深度和中度肌松状态,改善手术(尤其是腹腔镜手术)预后。
The discovery and application of muscle relaxants has led to major changes in modern anesthesia technology,promoting the rapid development of geriatric surgery,cardiac surgery and transplantation surgery.However,residual neuromuscular blockade that may accompany the use of muscle relaxants can seriously affect the prognosis of surgery.Owing to the obvious limitations,neostigmine,a traditional reversal agent grouped as cholinesterase inhibitor,cannot meet clinical needs.The new reversal agent,sugammadex,can accurately and quickly reverse the depth and moderate muscle relaxation and improve the prognosis of surgery,especially in laparoscopic surgery.
作者
吴新民
WU Xin-min(Department of Anesthesiology, Peking University First Hospital, Beijing 100034, China)
出处
《临床药物治疗杂志》
2019年第6期32-34,80,共4页
Clinical Medication Journal
关键词
肌肉松弛
肌松残留
深肌松
舒更葡糖钠
腹腔镜
muscle relaxation
residual neuromuscular blockade
deep neuromuscular blockade
sugammadex
laparoscopic
