摘要
目的系统评价非去极化肌松药对琥珀胆碱术后肌痛预防的有效性,为临床预防琥珀胆碱术后肌痛提供证据。方法计算机检索Pub Med、EMbase、The Cochrane Library(2014年第2期)、Wan Fang Data、CBM、CNKI,查找有关非去极化肌松药对琥珀胆碱术后肌痛预防有效性的随机对照试验(RCT)。检索时限均为从建库至2014年3月。由2位评价员按照纳入与排除标准独立筛选文献、提取资料和评价纳入研究的方法学质量后,采用Rev Man 5.2软件进行Meta分析。结果最终纳入11个RCT,共计666例患者。Meta分析结果显示:非去极化肌松药预处理对琥珀胆碱术后24 h肌痛有一定的预防作用[RR=0.46,95%CI(0.39,0.55),P<0.000 01],但对琥珀胆碱术后48 h肌痛的预防效果尚待评估。结论罗库溴铵与阿曲库铵为预防琥珀胆碱术后肌痛的有效药物。受纳入研究数量和质量限制,上述结论尚需更多高质量研究加以验证。
Objective To systematically review the effectiveness of non-depolarizing neuromuscular blockers for the prevention of succinylcholine-induced myalgia in clinical practice. Methods Databases including PubMed, EMbase, The Cochrane Library （Issue 2, 2014）, WanFang Data, CBM and CNKI were searched to collect the randomized controlled trails （RCTs） about non-depolarizing neuromuscular blockers for the prevention of succinylcholine-induced myalgia from inception to March 2014. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assessed methodological quality of included studies. Then meta-analysis was conducted using RevMan 5.2 software. Results A total of 11 RCTs involving 666 patients were included. The results of meta-analysis showed that： the pre-treatment of non-depolarizing neuromuscular blockers prevented succinylcholine-induced myalgia at 24 h after surgery （RR=0.46, 95%CI 0.39 to 0.55, P〈0.000 01）; however, the effectiveness of non-depolarizing neuromuscular blockers for prevention of succinylcholine-induced myalgia at 48 h after surgery was still unclear. Conclusion Current studies suggests that both rocuronium and atracurium are effective for the prevention of succinylcholine-induced myalgia. However, due to limited quantity and quality of the included studies, more high-quality studies are needed to verify the abovementioned conclusion.
出处
《中国循证医学杂志》
CSCD
2015年第1期62-68,共7页
Chinese Journal of Evidence-based Medicine
基金
新疆维吾尔自治区高校科研计划科学研究重点项目(编号:XJEDU2013I21)
关键词
琥珀胆碱
术后肌痛
非去极化肌松药
系统评价
META分析
随机对照试验
Succinylcholine
Myalgia
Non-depolarizing neuromuscular blocker
Systematic review
Meta-analysis
Randomized controlled trial
