摘要
目的 :研究氯胺酮对琥珀胆碱所致血K+ 、CK升高和术后肌痛的影响。方法 :30例全麻病人随机分为两组 ,氯胺酮组 (K组为实验组 )麻醉诱导采用静注安定 0 3mg/kg ,氯胺酮 2mg/kg ,琥珀胆碱 1 5mg/kg快速气管插管 ;硫贲妥钠组 (S组为对照组 )麻醉诱导采用静注安定 0 3mg/kg ,硫贲妥钠 6mg/kg ,琥珀胆碱 1 5mg/kg快速气管插管。两组病人均在麻醉前、注入琥珀胆碱后 1min、2min、3min、5min检测血K+ 、CK ,麻醉后 2 4hr询问病人非手术区肌痛情况。结果 :麻醉前两组血K+ 、CK无明显差别 (P >0 0 5 )而在注入琥珀胆碱后 1min、2min、3minK组血K+ 、CK明显低于S组 (P <0 0 5 )。麻醉后 2 4hr病人非手术区肌痛发生率K组为 13 33% (2 /15 ) ,S组为 5 3 33% (8/15 )。结论 :氯胺酮对琥珀胆碱所致血K。
Objective:To investigate the effects of ketamine on biochemical changes and postoperative myalgia induced by suxamethonium.Method:Thirty patients(ASAI),scheduled for elective surgery requiring general anesthesia,were randomly divided into two groups,ketamine group(K group)and thiopental sodium group(S group as control).MAP?HR?Spo2?ECG were measured in all patients during operative time.The anesthesia of K group was induced with diazepam 0.3mg/kg,ketamine 2mg/kg,suxamethonium 1.5mg/kg intravenously.In S group,the anesthesia was induced with diazepam 0.3mg/kg,thiopental 6mg/kg suxamethonium1.5mg/kg intravenously.The potassium-ion(K +)and creatinephosphokinase(CK) of blood were monitored before anesthesia and 1min?2min?3min?5min after injecting suxamethonium in two groups.The incident rate of myalgia were statisticed 24hr after anesthesia in two groups.Result:Non significant changes occured in K + and CK groups before anesthesia (P>0.05),but the K + and CK of K group was lower than S group 1min?2min?3min after injecting suxamethoniam (P<0.05).The myalgia incident rate of K group was 13.33%(2/15),the S group's was 53.33%(8/15).Conclusion:Ketamine contrasted with thiopental sodium may depress the increase of K + and CK induced by suxamethonium,but the mechanism is not distinct.Ketamine may also reduce the incident of myalgia.
出处
《内蒙古医学杂志》
2002年第4期327-328,共2页
Inner Mongolia Medical Journal
