摘要
目的:观察药物治疗症状性动脉导管未闭(symptomatic patent ductus arteriosus,s PDA)对早产儿预后的意义。方法:符合s PDA诊断标准的早产儿92例,随机给予对乙酰氨基酚口服(每次15 mg·kg^-1,q 6 h×3d)或者布洛芬口服(每次10 mg·kg^-1,q d×3d),如动脉导管未关闭,立即开始第二疗程,治疗方法同第一疗程。比较两个疗程结束后动脉导管成功关闭组和未关闭组早产儿之间机械通气天数、经鼻持续气道正压通气(Nasal Continuous Positive Airway Pressure,NCPAP)天数、达到全肠内营养的日龄、住院天数,以及支气管肺发育不良(bronchopulmonary dysplasia,BPD)、坏死性小肠结肠炎(necrotizing enterocolitis,NEC)、脑室周围-脑室内出血(periventricular-intraventricular hemorrhages,PIVH)的发生率。结果:两个疗程结束后,动脉导管关闭的早产儿75例,动脉导管未关闭的早产儿17例。动脉导管关闭组与未关闭组早产儿在胎龄、出生体重、达到全肠内营养的日龄、机械通气天数、住院天数等方面比较差异无统计学意义,BPD、NEC、PIVH发生率比较差异无统计学意义,动脉导管关闭组早产儿NCPAP天数短于动脉导管未关闭组早产儿[13(5,28)vs 32(18,36),(P<0.05)]。结论:药物治疗症状性动脉导管未闭有助于缩短早产儿无创呼吸支持天数。
Objective: To observe the significance of drug therapy for symptomatic patent ductus arteriosus (sPDA) in the prognosis of premature infants. Methods: 92 premature infants who met the diagnostic criteria of sPDA were randomly given paracetamol (15 mg·kg^-1 ,q 6 h×3 d) or ibuprofen (10 mg·kg^-1 ,q d×3 d). If the ductus arteriosus was not closed,the second course of treatment was started immediately,and the administration method was the same as the first course of treatment. The days of mechanical ventilation,the days of nasal continuous positive airway pressure (NCPAP),time of reaching total enteral nutrition,hospitalization days and the incidence of bronchopulmonary dysplasia (BPD),necrotizing enterocolitis (NEC),and periventricular-intraventricular hemorrhages (PIVH) were compared between the ductus arteriosus closed group and the unclosed group. Results: Among all the objects observed,there were 75 premature infants whose ductus arteriosus were successfully closed after the end of the two courses. There were no significant differences in gestational age,birth weight,time of reaching total enteral nutrition,mechanical ventilation days,hospitalization days and the incidence of BPD,NEC,and PIVH between the ductus arteriosus closed group and the unclosed group.The days of NCPAP in premature infants whose ductus arteriosus were successfully closed were shorter than that in premature infants whose ductus arteriosus were not closed [13(5,28) vs 32(18,36),( P <0.05)]. Conclusions: Drug treatment of symptomatic patent ductus arteriosus can help shorten the days of NCPAP in premature infants.
作者
陈俊
田鸾英
吴秀娟
赵月乔
杨亚娟
吕钊志
何泳聪
CHEN Jun;TIAN Luan-ying;WU Xiu-juan;ZHAO Yue-qiao;YANG Ya-juan;LV Zhao-zhi;HE Yong-cong(Department of Neonatology,Nanshan District Women's and Children's Health Hospital of Shenzhen,Shenzhen,Guangdong 518052)
出处
《赣南医学院学报》
2019年第6期570-573,共4页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
基金
深圳市科技计划项目基础研究类(编号:JCYJ20150402100128585)
关键词
对乙酰氨基酚
布洛芬
动脉导管未闭
预后
早产儿
paracetamol
ibuprofen
patent ductus arteriosus
prognosis
premature infants
