摘要
肝纤维化及终末期肝硬化常伴随肝脏缺氧现象,缺氧诱导因子1α作为调控机体缺氧反应的关键转录因子,在肝星状细胞活化和肝纤维化发生发展中扮演重要角色。此外,缺氧诱导因子1α表达下调可减轻肝纤维化,有望成为肝纤维化治疗新靶点。综述了缺氧诱导因子1α与肝纤维化相关信号通路及基因之间的关系,进一步讨论了缺氧诱导因子1α作为肝纤维化治疗新靶点的潜力。
Liver fibrosis and end-stage liver cirrhosis are often accompanied by liver hypoxia. As a key transcription factor for regulating the body’s response to hypoxia, hypoxia-inducible factor 1α(HIF-1α) plays an important role in the activation of hepatic stellate cells and the development and progression of liver fibrosis. In addition, downregulation of HIF-1α expression can alleviate liver fibrosis and thus HIF-1α is expected to become a new target for the treatment of liver fibrosis. This article reviews the association between HIF-1α and liver fibrosis-related signaling pathways and genes and further discusses the potential of HIF-1α as a new therapeutic target for liver fibrosis.
作者
周丹
张立婷
李俊峰
王珊
肖萍
ZHOU Dan;ZHANG Liting;LI Junfeng(The First Clinical Medical College,Lanzhou University,Lanzhou 730000,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2019年第7期1604-1607,共4页
Journal of Clinical Hepatology
基金
国家自然科学基金项目(31570509)
国家自然科学基金项目(81800528)
甘肃省科技重大专项(1602FKDA001)
甘肃省生物治疗与再生医学重点实验室开放课题(zdsyskfkt-201701)
关键词
缺氧诱导因子1
Α亚基
肝硬化
信号传导
hypoxia-inducible factor 1, alpha subunit
liver fibrosis
signal transduction
