摘要
肝星状细胞(hepatic stellate cells,HSCs)活化、细胞外基质大量形成是肝纤维化发生发展的关键环节.许多研究发现,抑制HSCs增殖、促进HSCs凋亡可阻断肝纤维化进程;同时研究发现,促进活化HSCs衰老也可为肝纤维化的防治提供新的策略.本文就HSCs衰老与增殖、凋亡的关系以及在肝纤维化中的作用相关研究进展予以综述.
The activation of hepatic stellate cells（HSCs）in resting state and the secretion of numerous extracellular matrix are important for the development of liver fibrogenesis. Numerous studies suggest that inhibiting the activation and proliferation of HSCs and promoting apoptosis of HSCs can interrupt the progression of liver fibrosis. Promoting the senescence of activated HSCs can also provide a new strategy for the prevention and treatment of liver fibrosis. This paper discusses the relationship between senescence, proliferation, and apoptosis of HSCs as well as the role of HSCs in hepatic fibrosis.
出处
《世界华人消化杂志》
CAS
2017年第16期1469-1474,共6页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.81373465~~
