摘要
As a ligand-dependent transcriptional factor, peroxisome proliferator-activated receptor （PPAR） γ was expressed in several human cancer cells and PPARγ activation could induce cells growth inhibition. In this study we investigated the PPARγ expression in colon cancer cell line HT-29 and checked the inducement of apoptosis by two PPARγ specific agonists rosiglitazone and 15d-PGJ2. In addition, we also observed the protein expressions of PTEN and p-Akt1 before and after treatment with rosiglitazone and examination whether activation of PPARγ could increase the expression of PTEN in colon cancer cells.
As a ligand-dependent transcriptional factor, peroxisome proliferator-activated receptor （PPAR） γ was expressed in several human cancer cells and PPARγ activation could induce cells growth inhibition. In this study we investigated the PPARγ expression in colon cancer cell line HT-29 and checked the inducement of apoptosis by two PPARγ specific agonists rosiglitazone and 15d-PGJ2. In addition, we also observed the protein expressions of PTEN and p-Akt1 before and after treatment with rosiglitazone and examination whether activation of PPARγ could increase the expression of PTEN in colon cancer cells.
基金
This work was supported by a grant from the 135 Medical ImportantTalent Foundation of Jiangsu Province (No.37RC2002037).
