摘要
目的探讨世居青海的藏汉族人乳腺浸润性导管癌组织中Bcl-2、Bax及Caspase-3和凋亡指数(AI)的表达差异。方法采用免疫组织化学法检测藏族和汉族各60例乳腺浸润性导管癌中Bcl-2、Bax及Caspase-3蛋白的表达;采用原位DNA缺口末端标记法检测凋亡指数。结果藏族、汉族乳腺浸润性导管癌组织中Bcl-2的表达率分别为52.2%和38.3%,Bax表达率分别为76.7%和61.7%,Caspase-3表达率分别为60.0%和58.3%,藏族、汉族乳腺浸润性导管癌组织中AI阳性率分别为61.2%和60.0%,差异均无统计学意义(P>0.05)。结论世居青海的藏族和汉族乳腺浸润性导管癌组织中Bcl-2、Bax及Caspase-3的表达无差异,且乳腺浸润性导管癌组织中AI表达比较也无差异。
Objective To investigate the expressions of Bcl-2, Bax, Caspase-3 and apoptotic index (AI) in breast invasive ductal cancer between different ethnic groups, and to analyze their correlations with clinicopathological characteristics. Methods The expressions of Bcl-2, Bax and caspase-3 in breast invasive ductal cancers of 60 cases each of Tibetan and ethnic Han were examined with immunohistochemical stain in histopathologic slides. AI was detected by TUNEL method. Results The positive expression rates of Bcl-2 in breast invasive ductal cancer of Tibetan and ethnic Han were 52.2% and 38.3% respectively (P > 0.05);the positive expression rates of Bax were 76.7% and 61.7% respectively (P > 0.05);the positive expression rates of Caspase-3 were 60.0% and 58.3% respectively (P > 0.05);the AI was 61.2% and 60% respectively (P > 0.05). Conclusions The positive expression rates of Bcl-2, Bax and caspase-3 of breast invasive ductal cancers between Tibetan and ethnic Han demonstrate no statistically difference, and AI didn’t show any difference either.
作者
杨娟
李亚飞
宋晓燕
袁青玲
祁玉娟
Juan Yang;Ya-fei Li;Xiao-yan Song;Qing-ling Yuan;Yu-juan Qi(Qinghai Provincial People’s Hospital,Xining,Qinghai 810007,China)
出处
《中国现代医学杂志》
CAS
2019年第14期24-30,共7页
China Journal of Modern Medicine
基金
青海省自然科学基金青年项目(No:2012-Z-940Q)
