摘要
近年来,透明质酸(hyaluronic acid,HA)作为一种高效的肿瘤靶向递送载体引起了人们的广泛关注。HA的优越性主要体现在其具备良好的生物相容性、生物可降解性和特殊的CD44受体结合能力。本文针对HA的结构修饰、作为肿瘤特异性药物载体的基础理论以及基于HA纳米递药系统的研究成果进行了综述,并展望了其应用前景。
Hyaluronic acid(HA) has coming before the public in recent years for its potential application as an efficient tumor-targeting delivery vehicle.The superiority of HA is reflected as its great biocompatibility,biodegradability and special binding ability to CD44 receptor.Thus,in this review,the discussion is focused on the structural modification of HA,the rationale for the use of HA as tumor-specific carrier for drug delivery and research achievements in the field of HA-based nanodrug delivery systems.In addition,the application prospect of HA is prospected.
作者
陈奋
杨月
张玲
潘卫三
CHEN Fen;YANG Yue;ZHANG Ling;PAN Weisan(Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Department of Pharmaceutics,School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China;The First Affiliated Hospital of China Medical University,Shenyang 110001,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2019年第13期1704-1710,共7页
Chinese Journal of Modern Applied Pharmacy
基金
国家自然科学基金青年项目(81703709,81703425)
辽宁省科技厅博士科研启动基金项目(201601186)
中国博士后科学基金资助项目(2018M641716)
关键词
透明质酸
肿瘤靶向递送载体
结构修饰
纳米递药系统
hyaluronic acid
tumor-targeting delivery vehicle
structural modification
nanodrug delivery systems
