摘要
目的研究纳米氢氧化镧对大鼠慢性肾衰竭致高磷血症的治疗作用,并与碳酸镧和普通粒径氢氧化镧的治疗作用进行比较。方法建立纳米氢氧化镧的合成工艺,通过腺嘌呤(0.2g·kg^-1)对60只Wistar大鼠建立慢性肾衰竭高磷血症动物模型,随机分为纳米氢氧化镧高、中、低剂量组(0.15,0.1,0.05g·kg^-1)、碳酸镧组(0.3g·kg^-1)、普通粒径氢氧化镧组(0.1g·kg^-1)和模型组。另取20只Wistar大鼠,随机分为空白组和纳米氢氧化镧空白给药组。检测血清磷、尿液磷、血清肌酐、尿液肌酐、血尿素氮、尿液尿素氮、肾脏系数、甲状旁腺激素等生化指标,比较纳米氢氧化镧与普通磷结合剂对于高磷血症的治疗作用。结果与模型组比较,纳米氢氧化镧(0.1g·kg^-1)对高磷血症大鼠中的血清磷、血清肌酐、尿液尿素氮、肾脏系数有降低作用并且有显著性差异(P<0.05);与碳酸镧和普通粒径氢氧化镧相比有降低作用,但没有显著性差异。结论纳米氢氧化镧与碳酸镧相比具有更高的效价,可以作为后续开发的新型磷结合剂。
OBJECTIVE To observe the therapeutic effects of nano-lanthanum hydroxide(Nano-LH) on hyperphosphatemia rats,and to compare the therapeutic effects with lanthanum carbonate and common particle size lanthanum hydroxide.METHODS A synthetic process of Nano-LH was established.Animal model of hyperphosphatemia in 60 Wistar rats with chronic renal failure was established by adenine(0.2 g·kg^-1),and the model rats were randomly divided into high, middle and low dose groups of Nano-LH(0.15,0.1,0.05 g·kg^-1),lanthanum carbonate group(0.3 g·kg^-1),normal particle size lanthanum hydroxide group(0.1 g·kg^-1) and model group.Another 20 Wistar rats were randomly divided into blank control group and blank administration group of Nano-LH.Biochemical indicators such as serum phosphorus,urine phosphorus,serum creatinine(Scr),urine creatinine,blood urea nitrogen(BUN),urine urea nitrogen,kidney index(KI) and parathyroid hormone were examined and the therapeutic effects of Nano-LH and common renagel on hyperphosphatemia were compared.RESULTS Compared with the model group,Nano-LH(0.1 g·kg^-1) had a lowering effect on serum phosphorus,Scr,BUN and KI in the hyperphosphatemia rats with significant differences(P<0.05).And it had a lowering effect than lanthanum carbonate and normal partical size lanthanum hydroxide,but there was no significant difference.CONCLUSION Nano-LH has higher potency than lanthanum carbonate,and can be a new phosphorus binder developed later.
作者
赵璐璐
马子兴
俞腾飞
武燕
刘丹丹
张晓菲
苗鑫
邢海燕
李刚
ZHAO Lulu;MA Zixing;YU Tengfei;WU Yan;LIU Dandan;ZHANG Xiaofei;MIAO Xin;XING Haiyan;LI Gang(Inner Mongolia Medical University,Hohhot 010100,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2019年第12期1449-1455,共7页
Chinese Journal of Modern Applied Pharmacy
基金
国家自然科学基金项目(81560685)
关键词
肾衰竭
高磷血症
纳米氢氧化镧
碳酸镧
chronic renal failure
hyperphosphatemia
nano-lanthanum hydroxide
canthanum hydroxide
