摘要
目的探讨无乳链球菌的临床分离及药物敏感性,为B群链球菌感染的临床诊治提供参考。方法采集2015年1月至2017年12月期间,来该院就诊的孕期在35-37周孕妇的阴道拭子和肛周拭子,进行B群链球菌的分离及鉴定,并对分离菌株进行药敏试验。结果28090份标本中GBS共计分离菌株2753株,阳性率9.80%(2753/28090);其中,肛周拭子GBS阳性率为9.82%(1379/14045);阴道拭子GBS阳性率为9.78%(1373/14045);经统计学分析,肛周拭子和阴道拭子GBS检出率无统计学差异(P<0.05)。同一孕妇肛周拭子和阴道拭子同时检出GBS的概率为38.13%。药敏结果显示GBS对青霉素、万古霉素、替加环素、利奈唑胺、氨苄西林的耐药率为0%;对左氧氟沙星、莫西沙星和环丙沙星保持中等水平耐药,耐药率率分别是29%、29%、31%;红霉素、克林霉素、四环素的耐药率为71%、82%和86%。结论本地区孕妇携带GBS阳性率9.80%,对红霉素、克林霉素和四环素的耐药率较高,临床应积极开展GBS的常规检测并重视抗菌药物的合理应用。
Objective To explore the clinical isolation and drug sensitivity of Streptococcus agalactiae,and to provide reference for the clinical diagnosis and treatment of group B streptococcal infection.Methods During the period from January 2015 to December 2017,we collected vaginal swabs and perianal swabs from 35-37 weeks pregnant women in our hospital for the isolation and identification of group B streptococci.Sensitivity test.Results Among the 28 090 specimens,2 753 strains were isolated from GBS,the positive rate was 9.80%(2 753/28 090).Among them,the positive rate of GBS in the perianal swab was 9.82%(1 379/14 045);the positive rate of GBS in the vaginal swab was 9.78%(1373)./14 045);Statistical analysis showed that there was no significant difference in the rate of GBS between perianal swabs and vaginal swabs ( P <0.05).The probability of simultaneous detection of GBS in the same pregnant woman′s perianal swab and vaginal swab was 38.13%.Drug susceptibility results showed that GBS resistance to penicillin,vancomycin,tigecycline,linezolid,ampicillin was 0%;moderate resistance to levofloxacin,moxifloxacin and ciprofloxacin,resistance The rate rates were 29%,29%,and 31%,respectively;the resistance rates of erythromycin,clindamycin,and tetracycline were 71%,82%,and 86%.Conclusion The positive rate of GBS in pregnant women in this region is 9.80%,and the resistance rate to erythromycin,clindamycin and tetracycline is high.The clinical examination of GBS should be carried out actively and the rational application of antibiotics should be emphasized.
作者
郝同雨
龚海娜
张巍
刘小柳
柏芹
杜丽伟
莫红梅
HAO Tongyu;GONG Haina;ZHANG Wei;LIU Xiaoliu;BAI Qing;DU Liwei;MO Hongmei(Shenzhen Luohu People′s Hospital,Shenzhen,518000,Guangdong,China;Medical Laboratory ofShenzhen Luohu District Maternal and Child Health Hospital,Shenzhen 518001,China,Guangdong518000,China;Shenzhen Newborn Genetic Disease Screening Center,Guangdong 518000,China)
出处
《国际检验医学杂志》
CAS
2019年第A01期21-24,共4页
International Journal of Laboratory Medicine
基金
广东省深圳市医疗卫生工程项目(SZSM201601062)。
关键词
孕妇
B群链球菌
药物敏感性
pregnant woman
group B streptococcus
drug sensitivity
