摘要
邻苯二甲酸酯(PAEs)作为添加剂被广泛应用于食品、建材、医疗等各行各业中。由于PAEs难以形成强力的共价键,PAEs会不断泄露到环境中并通过人们的饮食、日常生活用品接触等在人体中蓄积。作为环境内分泌干扰物中的一大类,PAEs会造成影响深远的生殖内分泌干扰效应,对配子及胚胎发育产生影响。而Wnt家族基因及其产物可通过多环节、多作用位点影响基因表达或促进细胞增殖,从而诱导组织分化来调控生长发育。综述PAEs的生化性质和污染途径以及PAEs的内分泌干扰机制,并综述Wnt及其他可能介导PAEs对配子及胚胎发育造成影响的信号通路或机制。
Phthalates(PAEs) are widely used as additives in food, building materials, medical and other industries. Because PAEs are difficult to form strong covalent bonds, they will continue to leak into the environment and be absorbed during people’s daily life. As a large class of environmental endocrine disruptors that disrupt reproductive endocrine, PAEs affect gametes and embryo development strongly. The factors of Wnt family participate in the regulation of tissue differentiation, growth and development via multiple mechanisms such as affecting gene expression and inducing cell proliferation. This paper reviews the biochemical character, endocrine disruption mechanisms and pollution conditions of PAEs, and the related Wnt signaling pathways that may affect gametes and embryo development.
作者
汪晨曦
黄巧瑶
马天仲
WANG Chenxi;HUANG Qiao-yao;MA Tian-zhong(Reproductive Medicine Center,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,Guangdong Province,China)
出处
《国际生殖健康／计划生育杂志》
CAS
2019年第4期305-308,327,共5页
Journal of International Reproductive Health/Family Planning
基金
国家自然科学基金(81300484)
广东省自然科学基金(2018A0303130308)
广东省医学科研基金(B2019007)
