摘要
反复自然流产是指同一患者连续2次或2次以上的自然流产,是妇产科常见的并发症之一。其中,不明原因反复自然流产占比40%~80%。随着医学水平的不断进步,生殖免疫学研究也不断发展,众多研究发现反复自然流产的发生大多与免疫因素有关。尤其近年来对T细胞活化及分化方面关注点的增多,使其在反复自然流产发病机制中的作用越来越备受关注。Th17细胞和Treg细胞作为CD4+T细胞的亚群,两者之间的失衡将导致机体免疫监视及免疫耐受功能受损。因此,本文将对Th17/Treg细胞在反复自然流产中的作用进行概述。
Recurrent spontaneous abortion (RSA) refers to two or more consecutive spontaneous abortions in the same patient and is one of the common complications in obstetrics and gynecology.Among them,unexplained RSA accounts for 40%~80%.With the continuous advancement of medical level,research on reproductive immunology has also continued developing,and it is believed that the occurrence of RSA is mostly related to immune factors.In particular,the increasing focus on T cell activation and differentiation has made it more and more attractive in the pathogenesis of RSA.Th17 cells and Treg cells,as a subset of CD4 +T cells,whose imbalance will lead to impair of immune surveillance and immune tolerance.Therefore,this article will briefly describe the role of Th17/Treg cells in recurrent abortion.
出处
《妇产与遗传（电子版）》
2019年第1期43-46,共4页
Obstetrics-Gynecology and Genetics (Electronic Edition)
