摘要
诱导性多功能干细胞(iPSC)是通过向体细胞中导入一些特定的多能性转录因子使其重编程为干细胞。相比于传统干细胞,iPSC具有多方面优势,如来源广泛并且可以全能分化,以及更少涉及胚胎干细胞长期争议的取材和伦理问题。在皮肤科,iPSC可以用于制造再生皮肤,构建皮肤疾病模型,为研究皮肤疾病的发病机制提供新的平台,还可以针对特定皮肤疾病进行细胞治疗或基因修正治疗。目前其效果已在动物模型中得到验证,临床试验也正在逐步进行。
Induced pluripotent stem cells (iPSCs) are a kind of stem cells induced from somatic cells by reprogramming with some specific pluripotent transcription factors. Compared with traditional stem cells, iPSCs have many advantages, including a wide range of sources, the ability of totipotent differentiation, and less ethical and sourcing issues associated with embryonic stem cells which have been debated for a long time. In dermatology, iPSCs can be used to make regenerative skin, establish models of skin diseases, provide a new platform for studying the pathogenesis of skin diseases, and perform cell treatment or gene modification treatment for specific skin diseases. At present, the application value of iPSCs has been verified among animal models, and clinical trials are also under way.
作者
李遇梅
张怡萱
刘莉萍
Li Yumei;Zhang Yixuan;Liu Liping(Department of Dermatology, Affiliated Hospital of Jiangsu University, The Key Laboratory of Immunological Dermatology in Zhenjiang, Zhenjiang 212000, Jiangsu, China)
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2019年第7期445-449,共5页
Chinese Journal of Dermatology
基金
国家自然科学基金(81573053)
镇江市第七批科技计划项目(SS2015024).
关键词
多能干细胞
再生医学
皮肤疾病
疾病模型
动物
基因疗法
诱导性多功能干细胞
Multipotent stem cells
Regenerative medicine
Skin diseases
Disease models
animal
Gene therapy
Induced pluripotent stem cells
