摘要
目的 观察火针联合药物治疗白癜风的临床疗效。方法 将98例稳定期白癜风患者随机分为联合组和对照组,每组49例。对照组予以0.1%他克莫司软膏外敷联合中药活血消白汤口服,联合组在对照组基础上采用火针治疗。比较两组治疗前及治疗6周、12周后皮损面积,比较两组治疗前后外周血效应性T细胞(effector T cell, Teff)[辅助性T细胞17(T helper cell 17, Th17)和辅助性T细胞22(T helper cell 22, Th22)]和调节性T细胞(regulatory T cell, Treg)含量,并比较两组治疗前后血清白细胞介素-17 (interleukin-17,IL-17)、白细胞介素-22(interleukin-22, IL-22)、白细胞介素-10(interleukin-10, IL-10)、转化生长因子-β(transforming growth factor-β, TGF-β)、CXC趋化因子配体10(CXC chemokine ligand 10, CXCL10)、CXC趋化因子配体16(CXC chemokine ligand 16, CXCL16)水平,并比较两组临床疗效。结果 治疗后6周、12周后,两组皮损面积均减小(P<0.01),联合组小于对照组(P<0.01)。治疗后,两组外周血Th17和Th22含量降低(P<0.01),Treg含量升高(P<0.01);联合组外周血Th17和Th22含量低于对照组(P<0.01),Treg含量高于对照组(P<0.01)。治疗后,两组血清IL-17和IL-22水平降低(P<0.01),IL-10和TGF-β水平升高(P<0.01);联合组血清IL-17和IL-22水平低于对照组(P<0.01),血清IL-10和TGF-β水平高于对照组(P<0.01)。治疗后,两组血清CXCL10和CXCL16水平均降低(P<0.01),联合组均低于对照组(P<0.01)。联合组总有效率高于对照组,差异有统计学意义(P<0.05)。结论 火针联合药物治疗白癜风疗效显著,可减小皮损面积,恢复机体Teff/Treg免疫平衡,下调血清CXCL10、CXCL16表达。
Objective To observe the clinical efficacy of fire needling combined with medication in the treatment of vitiligo.Method A total of 98 patients with stable vitiligo were randomly divided into the combination group and the control group,with 49 cases in each group.The control group was treated with 0.1%tacrolimus ointment combined with oral Huoxue-Xiaobai decoction,and the combination group was treated with fire needling in addition to the treatment used in the control group.The skin lesion area was compared between the two groups before treatment and after 6 weeks and 12 weeks of treatment.The effector T cell(Teff)[T helper cell 17(Th17)and T helper cell 22(Th22)]and regulatory T cell(Treg)in peripheral blood were compared between the two groups before and after treatment,and the serum levels of interleukin-17(IL-17),interleukin-22(IL-22)and interleukin-10(IL-10,IL-22)transforming growth factor-b(TGF-b),CXC chemokine ligand 10(CXCL10)and CXC chemokine ligand 16(CXCL16)levels before and after treatment were compared between the two groups,and the clinical efficacy of the two groups was compared.Result After 6 weeks and 12 weeks of treatment,the skin lesion area of the two groups decreased(P<0.01),and it was smaller in the combination group than in the control group(P<0.01).After treatment,the levels of Th17 and Th22 in peripheral blood of the two groups were decreased(P<0.01),and the levels of Treg were increased(P<0.01).The levels of Th17 and Th22 in peripheral blood of the combination group were lower than those of the control group(P<0.01),and the level of Treg was higher than that of the control group(P<0.01).After treatment,the serum levels of IL-17 and IL-22 were decreased(P<0.01),and the levels of IL-10 and TGF-bwere increased(P<0.01)in the two groups.The serum levels of IL-17 and IL-22 in the combination group were lower than those in the control group(P<0.01),and the serum levels of IL-10 and TGF-bwere higher than those in the control group(P<0.01).After treatment,the serum levels of CXCL10 and CXCL16 in
作者
寇晓丽
耿春杰
王贺朋
范丽芳
王根会
郑树茂
KOU Xiaoli;GENG ChunJie;WANG Hepeng;FAN Lifang;WANG Genhui;ZHENG Shumao(Affiliated Hospital of Hebei Academy of Traditional Chinese Medicine,Shijiazhuang 050031,China;Xingtai Third Hospital,Xingtai 054000,China;Hebei Province Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,China)
出处
《上海针灸杂志》
CSCD
2023年第11期1166-1171,共6页
Shanghai Journal of Acupuncture and Moxibustion
基金
河北省中医药管理局科研计划项目(2021113)。
关键词
火针疗法
白癜风
针药并用
免疫功能
炎性因子
Fire needling
Vitiligo
Acupuncture-medication combined
Immune function
Inflammatory factors
