摘要
脓毒症发病率和死亡率双高,已成为威胁人类生命和生活的一种危险性疾病,同时发病急、病情重也是急诊及重症监护病房高死亡率的主要原因。近年来,关于脓毒症一直是探讨的热点问题,目前脓毒症发生及发展机制也正在研究之中,但具体的发病原因仍不明朗,线粒体氧化应激损伤、血管内皮损伤等,都是研究的相关内容。许多研究表明自噬是蛋白质和细胞器的循环途径,可以降解或循环一些不必要和多余的细胞成分,并在脓毒症中发挥着重要作用,本研究就自噬在脓毒症方面的研究进行概述,以期为临床脓毒症的研究提供依据,为寻找有效治疗方法奠定基础。
The high incidence and mortality of sepsis has become a dangerous disease threatening human living and life. At the same time, acute onset and serious illness are the main reasons for high mortality in emergency and intensive care units. In recent years, sepsis has been a hot topic of discussion. At present, the mechanism of sepsis occurrence and development is also under study. However, the specific causes of sepsis are still unclear. Mitochondrial oxidative stress injury, vascular endothelial injury and so on are all related research contents. Many studies have shown that autophagy is a circulatory pathway of proteins and organelles, which can degrade or recycle some unnecessary and redundant cellular components and play an important role in sepsis. This study summarizes the research on autophagy in sepsis, with a view to providing a basis for clinical sepsis research and laying a foundation for finding effective treatment methods.
作者
李雯
练睿
沈美佳
薛云允
孙力超
LI Wen;LIAN Rui;SHEN Meijia;XUE Yunyun;SUN Lichao(Department of Emergency,China-Japan Friendship Hospital,Beijing 100029,China)
出处
《中国继续医学教育》
2019年第19期160-164,共5页
China Continuing Medical Education
基金
国家自然科学基金面上项目(81871600)
国家自然科学基金青年项目(81601725)
关键词
脓毒症
自噬
淋巴细胞
抗原呈递
器官
潜在治疗
sepsis
autophagy
lymphocyte
antigen presentation
organ
potential treatment
