摘要
目的:系统评价山莨菪碱注射液辅助治疗斑秃的有效性和安全性,为临床“超说明书用药”提供循证参考。方法:计算机检索PubMed、Cochrane library、中国期刊全文数据库(CNKI)、万方数据库收集山莨菪碱注射液辅助治疗斑秃的随机对照试验,检索时限均为建库至2018年11月30日。实验组单用山莨菪碱注射液或联合中药、西药等;对照组为单用中药、西药治疗,提取相关资料并按照Cochrane系统评价员手册5.1.0评价质量后,采用RevMan 5.3统计软件对数据进行Meta分析。结果:共纳入4个研究,合计350例患者。Meta分析结果显示,试验组患者总有效率显著高于对照组,差异有统计学意义(OR=4.05,95%CI:2.18~7.52,P<0.0001)。山莨菪碱注射液辅助治疗斑秃引起不良反应的发生率比较,差异无统计学意义(OR=1.16,95%CI:0.66~2.04,P=0.61)。结论:山莨菪碱注射液辅助治疗斑秃能显著提高斑秃近期疗效,提升有效率,且未增加不良事件的发生。
Objective To systematically review the efficacy and safety of anisodamine injection in the treatment of alopeciaareata,so as to provide evidence-based references for clinical off-label medication. Methods PubMed,Cochrane library,CNKI,and Wanfang databases were electronically searched to collect randomized controlled trials(RCTs)about anisodamine injection for alopeciaareata from inception to November 30,2017.The experimental group used anisodamine injection alone or combined with traditional Chinese medicine or western medicine;the control group was treated with traditional Chinese medicine or western medicine alone.Relevant information was extracted,andthe qualitywas evaluated according to the Cochrane Handbook for Systematic Reviews of Interventions 5.1.0.Meta-analysis was performed using Revman 5.3 software. Results Four RCTs involving 350 patients were included.The results of meta-analysis showed that,the total effective rate of patients in the experimental group was significantly higher than that in the control group.There was significant difference between two groups(OR=4.05,95%CI:2.18~7.52,P<0.0001). Therewas no significant difference in the incidence of adverse reactions caused by anisodamine injection in the treatment of alopecia areata(AA)(OR=1.16,95%CI:0.66~2.04,P=0.61). Conclusion Anisodamine injection in the treatment of alopecia areata can significantly improve the short-term effect,improve the efficiency,in addition,it does not increase the incidence of adverse events.
作者
张翠翠
李博
张镭
林阳
ZHANG Cui-cui;LI Bo;ZHANG Lei;LIN Yang(Department of Pharmacy,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China;Department of Pharmacy,China-Japan Friendship Hospital,Beijing 100029,China)
出处
《临床药物治疗杂志》
2019年第5期73-76,共4页
Clinical Medication Journal
基金
北京市医院管理局临床医学发展专项“杨帆”计划(ZYLX201805)
