摘要
目的:检测斑秃患者血清甲状腺自身抗体、促甲状腺素(TSH)及甲状腺激素的水平,探讨斑秃与自身免疫性甲状腺疾病的相关性。方法:收集斑秃患者157例,选择150例健康人为正常对照组。采用化学发光免疫分析法测定斑秃患者和正常对照组血清中抗甲状腺过氧化物酶抗体(anti-TPOAb)、抗甲状腺球蛋白抗体(anti-TGAb)、TSH及甲状腺激素[三碘甲腺原氨酸(T3)、四碘甲腺原氨酸(T4)]的水平。结果:斑秃患者血清中anti-TPOAb、anti-TGAb、TSH及T3水平与正常对照组比较,差异均有统计学意义(P<0.017),T4水平与正常对照组比较,差异无统计学意义(P>0.017);其中斑秃活动期组、稳定期组和轻型组的anti-TPOAb、anti-TGAb、TSH及T3水平与正常对照组比较,差异均有统计学意义(P<0.017);重型组的anti-TPOAb、anti-TGAb及T3水平与正常对照组比较,差异均有统计学意义(P<0.017),重型组的TSH水平与正常对照组比较,差异无统计学意义(P>0.017)。斑秃活动期组、稳定期组、重型组和轻型组的T4水平与正常对照组比较,差异均无统计学意义(P>0.017),活动期组与稳定期组、重型组的T4水平与轻型组比较,差异均无统计学意义(P>0.017)。斑秃患者组anti-TPOAb和anti-TGAb阳性率(17.8%、8.9%)与正常对照组(2.0%、1.3%)比较,差异有统计学意义(χ~2=21.187,P=0.000;χ~2=8.931,P=0.003)。结论:斑秃患者anti-TPOAb和anti-TGAb阳性率高,斑秃与自身免疫性甲状腺疾病可能存在一定的相关性,对斑秃患者,检测甲状腺自身抗体、TSH及甲状腺激素水平具有一定的临床意义。
Objective： To measure serum levels of thyroid autoantibodies, thyrotropin and thyroid hormones in patients with alopecia areata, and to explore the relationship between alopeeia areata and autoimmune thyroid diseases. Methods： The sam- ples were collected from 157 patients with alopecia areata. 150 gender- and age-matched healthy volunteers served as normal controls. Serum anti-thyroid peroxidase autoantibody（anti-TPOAb）, anti-thyroglobulin antibody（anti-TGAb） and thyroid hor- mones were measured using chemiluminescence immunoassay. Results： Regardless of the disease status and severity, the levels of anti-TPOAb, anti-TGAb, and T3, but not T4, were significantly higher in patients with alopecia areata than in the normal controls（P〈0.017）. TSH levels were also higher in patients with alopecia areata（except severe cases） than in the normal con- trois（P〈0.017）. T4 levels did not vary with disease status or severity. The positive rates of anti-TPOAb and anti-TGAb were higher in patients with alopecia areata than in normal controls（17.8% vs. 2.0% for anti-TPOAb, X2=21.187,P=0.000; 8.9% vs. 1.3% for anti-TGAb, X2=8.931 ,P=0.003）. Conclusion： The high positive rates of anti-TPOAb and anti-TGAb in patients with alopeeia areata suggest that autoimmune thyroid disease may be related to alopeeia areata. It is important to measure the lev- els of thyroid autoantibodies, TSH and thyroid hormones in patients with alopecia areata.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2018年第3期145-149,共5页
Journal of Clinical Dermatology
基金
遵义市科学技术基金[遵义市科合社字(2011)29号]
贵州省科技厅联合基金[黔科合LH字(2015)7474号]
贵州省中医药管理局科技基金(QZYY-2015-039)资助项目
