摘要
目的研究T淋巴斑点试验及腺苷脱氨酶(ADA)在结核性心包炎诊断中的临床价值。方法回顾性分析2015年1月至2018年6月我院收治的99例疑似结核性心包炎患者的临床资料,分别给予患者单纯T淋巴斑点试验检测、单纯ADA检测和T淋巴斑点试验联合ADA检测。对三种检测方式的诊断结果进行分析,计算其诊断准确率、灵敏度和特异度。结果99例疑似患者经病理活检发现阳性例数75例,阴性例数24例。T淋巴斑点试验检出真阳性63例,假阳性4例,真阴性20例,假阴性12例;ADA检测检出真阳性47例,假阳性11例,真阴性13例,假阴性28例;联合诊断检出真阳性72例,假阳性0例,真阴性24例,假阴性3例。联合诊断的准确率、灵敏度和特异度显著高于单纯T淋巴斑点试验及ADA检测,差异具有统计学意义(P<0.05);单纯T淋巴斑点试验的准确率、灵敏度和特异度显著高于单纯ADA检测,差异具有统计学意义(P<0.05)。结论T淋巴斑点试验和ADA在结核性心包炎诊断中均具有一定临床价值,但单纯T淋巴斑点试验的准确率、灵敏度和特异度高于单纯ADA检测,且两种诊断方式结合诊断的准确率、灵敏度和特异度更高,值得在临床上推广应用。
Objective To study the clinical value of T lymphoid spot test and adenosine deaminase (ADA) detection in the diagnosis of tuberculous pericarditis. Methods The clinical data of 99 patients with suspected tuberculous pericarditis admitted in our hospital from January 2015 to June 2018 were retrospectively analyzed. The patients were given single T-lymphoid spot test, ADA test and T-lymphoid spot test combined with ADA test. The diagnostic results of the three methods were analyzed, and the diagnostic accuracy, sensitivity and specificity were calculated. Results There were 75 positive cases and 24 negative cases in 99 suspected patients by pathologic biopsy. There were 63 cases of true positive, 4 cases of false positive, 20 cases of true negative and 12 cases of false negative detected by T lymph spot test. Forty-seven cases of true positive, 11 cases of false positive, 13 cases of true negative and 28 cases of false negative were detected by ADA. Seventy-two cases of true positive, 0 case of false positive, 24 cases of true negative and 3 cases of false negative were detected by combined diagnosis. The accuracy, sensitivity and specificity of combined diagnosis were significantly higher than those of single T lymphoid spot test and ADA test, and the differences were statistically significant (P<0.05). The accuracy, sensitivity and specificity of single T lymphoid spot test were significantly higher than those of single ADA test, and the differences were statistically significant (P<0.05). Conclusion Both T-lymphoid spot test and ADA have certain clinical value in the diagnosis of tuberculous pericarditis, but the accuracy, sensitivity and specificity of single T-lymphoid spot test are higher than those of single ADA test. The combination of the two diagnostic methods has higher accuracy, sensitivity and specificity, which is worth popularizing and applying in clinic.
作者
郑琴芳
ZHENG Qin-fang(Xi'an Chest Hospital, Xi'an 710000, China)
出处
《临床医学研究与实践》
2019年第19期101-103,共3页
Clinical Research and Practice
关键词
T淋巴斑点试验
腺苷脱氨酶
结核性心包炎
T lymphatic spot test
adenosine deaminase
tuberculous pericarditis
