摘要
目的探讨实时定量聚合酶链反应(PCR)、结核抗体(TB-Ab)、结核菌素(BCG-PPD)5IU皮试三种方法联合检测对菌阴结核病患者临床诊断的意义。方法依上述三种方法检测初治菌阴肺结核121例,结核性胸膜炎93例,肺外结核病41例,非结核疾病35例。结果PCR、TB-Ab、PPD检测对菌阴肺结核的阳性检出率依次为41.3%、37.2%、31.4%,对结核性胸膜炎的阳性检出率依次为30.1%、43.0%、34.4%,肺外结核病组的阳性检出率依次为46.3%、39.0%、34.1%。联合检测与单项检测的最高阳性率相比,菌阴肺结核由41.3%提高到75.2%,结核性胸膜炎由43.0%提高到73.1%,肺外结核组由46.3%提高到74.3%。结论三种方法联合检测对于菌阴结核病的诊断,具有实用意义。
Objective To evaluate the diagnostic value of 3 kinds of methods combination used for smear negative tuberculous. Methods The 3 testing methods were PCR, TB-Ab and BCG-PPD 5 IU skiu test. The 3 testing methods were individually managed respectively to 121 smear negative cases, 93 tuberculous pleurisy, 41 tuberculosis out of pulmonary and 35 non- tuberculosis respiratory patients in the control group. Results The positive detection rate of single test by PCR,TB-Ab and PPD for sputum TB negative respiratory patients were 41.3%, 37.2%, 31.4%, respectively. The rates for tuberculous pleurisy patients were 30. 1%, 43.0% , 34.4% respectively. The rates for tuberculosis out of pulmonary patients were 46.3%, 39. 0%, 34. 1% respectively. Conclusion It is valuable to use the methods combined in detection of smear negative tuberculosis patients.
出处
《临床肺科杂志》
2007年第9期933-934,共2页
Journal of Clinical Pulmonary Medicine
关键词
聚合酶链反应
结核抗体
结核菌素试验
结核/诊断
polymerase chain reaction
antibody tuberculosis
tuberculin test
tuberculosis/diagnosis
