摘要
目的探讨肝脏疾病患者血清甘胆酸(CG)测定的临床意义。方法采用COBASc501全自动生化分析仪对1004例病毒性肝炎患者(病毒性肝炎组)、52例肝纤维化患者(肝纤维化组)、217例肝硬化患者(肝硬化组)、53例肝癌患者(肝癌组)和114例健康对照者(健康对照组)进行血清CG测定。结果不同肝脏疾病组CG水平均明显高于健康对照组,差异均有统计学意义(P<0.05);其他常用生化指标,如天门冬氨酸氨基转移酶、γ-谷氨酰转肽酶、总胆汁酸(TBA)等在不同疾病组与健康对照组比较升高程度不同;TBA水平在病毒性肝炎组、肝纤维化组、肝硬化组、肝癌组中与CG均呈正相关(r=0.892、0.944、0.695、0.837,P=0.000);CG与其他常用生化指标比较,除在病毒性肝炎组受试者工作特征曲线下面积(AUC)低于AST外,CG在病毒性肝炎组、肝纤维化组、肝硬化组、肝癌组中的AUC均明显高于其他生化指标,各组CG的AUC分别为0.675、0.767、0.829、0.921,P=0.000,随着肝脏疾病严重程度增加,CG水平的诊断界值同样增高,病毒性肝炎组、肝纤维化组、肝硬化组、肝癌组CG诊断界值分别为1.82、1.83、2.26、2.28μg/mL。结论血清CG水平可作为肝细胞损害及严重程度判断的重要指标。
Objective To investigate the clinical significance of determination of serum cholyglycine (CG) in patients with liver disease. Methods The serum cholyglycine (CG) level of 1 004 cases of viral hepatitis (viral hepatitis group),52 cases of hepatic fibrosis (hepatic fibrosis group),217 cases of liver cirrhosis (liver cirrhosis group),53 cases of liver cancer (liver cancer group) and 114 healthy controls (healthy control group) was measured by COBAS c501 automatic biochemical analyzer. Results The CG level in different liver disease groups was significantly higher than that in healthy control group,and the differences were statistically significant( P < 0.05),while other commonly used biochemical indexes such as aspartate aminotransferase,γ-glutamyltransferase,total bile acid (TBA) were significantly higher in different disease groups than those in healthy control group,the level of TBA was positively correlated with CG in viral hepatitis group,hepatic fibrosis group,liver cirrhosis group and liver cancer group ( r =0.892,0.944,0.695,0.837, P =0.000).Compared with other commonly used biochemical indicators,the area under receiver operating characteristic curve (AUC) of CG in viral hepatitis group was lower than that of AST,and the AUC of CG in each disease group was significantly higher than that of other biochemical indicators.AUC value of CG in in viral hepatitis group,hepatic fibrosis group,liver cirrhosis group and liver cancer group was 0.675,0.767,0.829, 0.921 ( P = 0.000 ).The diagnostic threshold value of CG level increased with the increase of the severity of liver disease (the diagnostic threshold value of CG in viral hepatitis group,hepatic fibrosis group,liver cirrhosis group and liver cancer group was 1.82,1.83,2.26,2.28 μg/mL). Conclusion The level of serum CG could be used as one of the important indexes to distinguish liver cell damage and severity of liver disease.
作者
赵蓉
石亚玲
江笑文
黄继德
张战锋
ZHAO Rong;SHI Yaling;JIANG Xiaowen;HUANG Jide;ZHANG Zhanfeng(Department of Clinical Laboratory,the Eighth People′s Hospital ofGuangzhou,Guangzhou,Guangdong 510060,China;Department of Clinical Laboratory,FirstAffiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510405,China)
出处
《检验医学与临床》
CAS
2019年第13期1823-1825,1828,共4页
Laboratory Medicine and Clinic
关键词
肝脏疾病
甘胆酸
诊断
liver disease
cholyglycine
diagnosis
