摘要
目的 探讨持续气道正压通气(CPAP)治疗对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)并轻度认知障碍患者的影响。方法 选取2017年6月—2018年8月山西医科大学第二医院收治的OSAHS并轻度认知障碍患者42例,根据患者意愿分为对照组(n=20)和试验组(n=22),后对照组中1例、试验组中2例患者被剔除。对照组患者给予保守治疗,试验组患者给予CPAP联合保守治疗;两组患者均连续治疗60d。比较两组患者治疗前后睡眠呼吸指标〔呼吸暂停低通气指数(AHI)和最低血氧饱和度(LSaO2)〕及简易智能精神状态检查量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分、画钟测验30分评分法(CDT30)评分、词语流畅性测试(VFT)结果、数字广度测试(DST)结果、Stroop色词测试(SCWT)结果、Epworth嗜睡量表(ESS)评分。结果 (1)治疗前两组患者AHI、LSaO2及MMSE评分、MoCA评分、CDT30评分、VFT评分、DST顺背评分、DST倒背评分、SCWT-卡片C正确数、SCWT-卡片C耗时、SCWT-反应干扰量(SIE)正确数、SCWT-SIE耗时、ESS评分比较,差异无统计学意义(P>0.05)。治疗后试验组患者MoCA评分、DST倒背评分高于对照组,ESS评分低于对照组(P<0.05);两组患者MMSE评分、CDT30评分、VFT评分、DST顺背评分、SCWT-卡片C正确数、SCWT-卡片C耗时、SCWT-SIE正确数、SCWT-SIE耗时比较,差异无统计学意义(P>0.05)。(2)相关性分析结果显示,CDT30评分与OSAHS并轻度认知障碍患者LSaO2呈正相关(rs=0.353,P=0.028),SCWT-卡片C耗时与OSAHS并轻度认知障碍患者ESS评分呈正相关(rs=0.352,P=0.028)。结论 LSaO2、日间嗜睡与OSAHS并轻度认知障碍患者执行功能有关;短期CPAP治疗可有效改善OSAHS并轻度认知障碍患者日间嗜睡情况、总体认知功能、注意力和执行功能。
Objective To investigate the impact of continuous positive airway pressure(CPAP)ventilation on OSAHS patients complicated with mild cognitive impairment(MCI).Methods A total 42 OSAHS patients complicated with MCI were selected in the Second Hospital of Shanxi Medical University from June 2017 to August 2018,and they were divided into control group(n=20)and test group(n=22)according to the patients'wills,after that 1 case in control group and 2 cases in test group were eliminated.Patients in control group received conservative treatment,while patients in test group received CPAP ventilation based on conservative treatment;both groups continuously treated for 60 days.Index of sleeping and breathing(including AHI and LSaO2),MMSE score,MoCA score,CDT30 score,VFT reslult,DST reslult,SCWT reslult and ESS score were compared between the two groups before and after treatment.Results(1)No statistically significant difference of AHI,LSaO2,MMSE score,MoCA score,CDT30 score,VFT score,DST score in sequence,DST score in reversed sequence,correct number of SCWT-card C,time-consuming of SCWT-card C,correct number of SCWT-SIE,time-consuming of SCWT-SIE or ESS score was found between the two groups before treatment,nor was MMSE score,CDT30 score,VFT score,DST score in sequence,correct number of SCWT-card C,time-consuming of SCWT-card C,correct number of SCWT-SIE or time-consuming of SCWT-SIE was found between the two groups after treatment(P>0.05);after treatment,MoCA score and DST score in reversed sequence in test group were statistically significantly higher than those in control group,while ESS score in test group was statistically significantly lower than that in control group(P<0.05).(2)Correlation analysis results showed that,CDT30 score was positively correlated with LSaO2 in OSAHS patients complicated with MCI(rs=0.353,P=0.028),meanwhile time-consuming of SCWT-card C was positively correlated with ESS score(rs=0.352,P=0.028).Conclusion LSaO2 and daytime sleepiness are significantly correlated with the executive function i
作者
马腾
韩彦青
李东芳
王蓓
王志琪
MA Teng;HAN Yanqing;LI Dongfang;WANG Bei;WANG Zhiqi(Shanxi Medical University,Taiyuan 030000,China;Department of Neurology,Shanxi Provincial Cardiovascular Hospital,Taiyuan 030000,China;Department of Neurology,the Second Hospital of Shanxi Medical University,Taiyuan 030000,China;Department of Respiratory Medicine,the Second Hospital of Shanxi Medical University,Taiyuan 030000,China)
出处
《实用心脑肺血管病杂志》
2019年第5期93-98,共6页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
阻塞性睡眠呼吸暂停低通气综合征
认知障碍
持续气道正压通气
认知功能
执行功能
日间嗜睡
Obstructive sleep apnea hypopnea syndrome
Cognitive impairment
Continuous positive airwaypressure ventilation
Cognitive function
Executive function
Daytime sleepiness
