摘要
目的分析妊娠期缺铁性贫血患者血Hb、SF、PON1水平与围生结局的关系。方法将2017年1月至2018年12月间收治的100例妊娠期缺铁性贫血患者作为观察组,100例妊娠期正常女性作为对照组,检测血Hb、SF、PON1水平,采用Pearson相关分析Hb、SF、PON1水平与围生结局关系,绘制ROC曲线分析各指标单独及联合预测围生结局的应用价值。结果观察组患者血Hb、SF及PON1水平明显低于对照组,差异均有统计学意义(均P<0.05)。围生结局正常患者血Hb、SF及PON1水平明显高于围生结局不良组,差异存在统计学意义(均P<0.05)。血Hb、SF及PON1水平与围生结局均呈正相关(r=0.712、0.695、0.428,均P<0.05)。Hb、SF及PON1联合预测的灵敏度及特异度均高于各指标单独应用,差异有统计学意义(均P<0.05),联合预测的AUC高于各指标单独应用,差异有统计学意义(P<0.05)。结论妊娠期缺铁性贫血患者血Hb、SF及PON1水平呈显著降低,与围生结局呈显著正相关,3项指标联合检测可显著提高预测围生结局的价值。
Objective To analyze the serum Hb,SF and PON1 levels in patients with iron deficiency anemia during pregnancy and their relationship with perinatal outcomes.Methods From January 2017 to December 2018,100 pregnant women with iron deficiency anemia treated in Hangzhou Women’s hospital(study group)and 100 normal pregnant women(control group)were enrolled in the study.Serum levels of Hb,SF and PON1 were measured.Pearson correlation test was used to analyze the relationship of Hb,SF and PON1 levels with perinatal outcomes.ROC curve was generated to analyze the application value of these parameters in evaluation of perinatal outcomes.Results The serum levels of Hb,SF and PON1 in the study group were significantly lower than those in the control group(P<0.05);the levels of Hb,SF and PON1 in the patients with normal perinatal outcomes were significantly higher than those in the patients with poor perinatal outcomes(P<0.05);serum Hb,SF and PON1 levels were positively correlated with the perinatal outcomes(P<0.05).The sensitivity and specificity of combined application in predicting perinatal outcomes were higher than those of single application(P<0.05).The AUC of combined diagnosis was higher than that of single application of each index(P<0.05).Conclusion The serum levels of Hb,SF and PON1 in pregnant women with iron deficiency anemia are significantly lower than those in normal pregnant women,which are positively correlated with perinatal outcomes.The combined application of the three indicators can significantly improve the predictive value of perinatal outcomes.
作者
张琳
宋玮钕
黄桉风
ZHANG Lin;SONG Weinv;HUANG Anfeng(Department of Obstetrics,Hangzhou Women’s Hospital,Hangzhou 310008,China)
出处
《浙江医学》
CAS
2019年第12期1295-1297,1333,共4页
Zhejiang Medical Journal
