摘要
目的探讨舍曲林联合穴位刺激调控法治疗老年强迫症的疗效。方法将71例老年强迫症患者按随机数字表法分为两组,观察组(舍曲林联合穴位刺激调控法治疗)35例,对照组(单用舍曲林治疗)36例,共治疗12周。采用Yale-Brown强迫症量表(Y-BOCS)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、生活质量综合评定问卷(GQOLI-74)评价疗效及生活质量,并观察不良反应。结果治疗12周末,观察组总有效率(91.4%)高于对照组(72.2%),差异有统计学意义(P<0.05)。两组患者Y-BOCS评分随观测时间推移而降低(均P<0.05);观察组治疗后各时点Y-BOCS评分均低于对照组(均P<0.05)。治疗12周末,两组患者HAMA及HAMD评分均较治疗前明显降低(均P<0.05),GQOLI-74各因子评分及总分均较治疗前明显升高(均P<0.05);观察组HAMA及HAMD评分均低于对照组(均P<0.05),GQOLI-74各因子评分及总分均高于对照组(均P<0.05)。两组患者均无血常规、肝肾功能、尿常规等异常,未出现体重明显改变。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论与单用舍曲林比较,舍曲林联合穴位刺激调控法治疗老年强迫症的疗效更佳,能有效改善患者焦虑及抑郁情绪,提高患者生活质量。
Objective To assess the efficacy of sertraline combined with transcutaneous electrical acupoint stimulation in the treatment of geriatric obsessive-compulsive disorder.Methods Seventy-one elderly patients with obsessive-compulsive disorder wererandomly divided into two groups:35 patients were treated by sertraline combined with TEAS(study group)and 36 patients were treated by sertraline alonefor 12 weeks(control group).The efficacy,quality of life,and adverse reactions were assessed using the Yale-Brown Obsessive-compulsive Disorder Scale(Y-BOCS),the Hamilton Anxiety Scale(HAMA),the Hamilton Depression Scale(HAMD),and the General Quality of Life Inventory-74(GQOLI-74).Results At the end of 12-week treatment,the total effective rate of the study groupwas higher than that of the control group(91.4%vs.72.2%,P<0.05).The Y-BOCS scores decreased afterthe treatment in both groups(P<0.05),while Y-BOCS scores of the study group were lower than those of control group at each time point after treatment(P<0.05).At the end of the 12 th week,the HAMA and HAMD scores of the two groups were significantly lower than those before treatment(both P<0.05).The overall score and the scores of each items in GQOLI-74 were significantly higher than those before treatment(both P<0.05).The HAMA and HAMD scores of study group were lower than those of control group(P<0.05),and the overall score and the scores of each items in GQOLI-74 of study group were higher than those of control group(P<0.05).Conclusion Compared with sertraline alone,sertraline combined with TEAS is more effective in treatment of geriatric obsessive-compulsive disorder.It can effectively improve anxiety and depression and improve patients’quality of life.
作者
宁芳
冯斌
吴剑勇
骆利元
郑自力
NING Fang;FENG Bin;WU Jianyong(Second Clinical Medical College,Zhejiang Chinese Medical University,Hangzhou 310053,China)
出处
《浙江医学》
CAS
2019年第13期1402-1405,共4页
Zhejiang Medical Journal
基金
中医药行业科研专项项目(200807030)
关键词
穴位刺激调控法
舍曲林
强迫症
老年人
Transcutaneous electrical acupoint stimulation
Sertraline
Obsessive-compulsive disorder
Elderly
