摘要
目的:探讨β型血小板衍生生长因子受体(PDGFR-β)蛋白在宫颈鳞状细胞癌(简称鳞癌)及癌前病变组织中的表达及其临床意义。方法:收集宫颈病变和宫颈鳞癌标本共148例,依据病理诊断结果分为慢性宫颈炎症组、低级别鳞状上皮内病变(LSIL)组、高级别鳞状上皮内病变(HSIL)组及宫颈鳞癌组。采用免疫组化法检测PDGFR-β蛋白在宫颈鳞癌及癌前病变组织中的表达情况,并分析其表达与临床病理特征的相关性。结果:宫颈鳞癌组组织中PDGFR-β蛋白阳性表达率明显高于慢性宫颈炎症组、LSIL组、HSIL组(P<0.05);PDGFR-β蛋白表达与淋巴结转移、TNM分期及癌组织分化程度有关(P<0.05),而与患者年龄无明显相关性(P>0.05)。结论:PDGFR-β在宫颈鳞癌组织中高表达,且与肿瘤转移相关,其可能成为宫颈鳞癌的一个潜在辅助诊断因子及治疗靶点。
Objective: To investigate the expression and clinical significance of platelet derived growth factor receptor-β(PDGFR-β) protein in cervical squamous carcinoma and precancerous tissue. Methods: One hundred and forty-eight tissue cases of cervical lesions and cervical squamous cell carcinomas were collected,and according to pathological diagnosis results,it was divided into chronic cervical inflammation group,low-grade squamous intraepithelial lesion(LSIL) group,high-grade squamous intraepithelial lesion(HSIL) group and cervical squamous cell carcinoma group. The immunohistochemical method was used to detect the expression of PDGFR-β protein in cervical squamous carcinoma and precancerous tissue. Correlation of the expression with the clinical pathological parameters was analyzed. Results: The expression of PDGFR-β protein in cervical squamous cell carcinoma was significantly higher than that in the chronic cervical group,LSIL group and HSIL group( P <0.05). The expression level of PDGFR-β protein in the cervical squamous carcinoma group was related to the TNM stage and lymph node metastasis( P <0.05),but not related to the age( P >0.05). Conclusion: The high expression of PDGFR-β in cervical squamous cell carcinomas is associated with tumor metastasis,which may be a potential auxiliary diagnostic factor and therapeutic target in the treatment of cervical squamous cell carcinoma.
作者
张玉芳
任春丽
梁爽
张金环
郭艳巍
ZHANG Yufang;REN Chunli;LIANG Shuang;ZHANG Jinhuan;GUO Yanwei(Department of Obstetrics and Gynecology,the Affiliated Hospital of Chengde Medical College,Chengde 067000,China)
出处
《东南大学学报（医学版）》
CAS
2019年第3期498-501,共4页
Journal of Southeast University(Medical Science Edition)
基金
承德市科技支撑计划项目(201606A047)
关键词
宫颈鳞状细胞癌
癌前病变
β型血小板衍生生长因子受体
免疫组织化学
cervical squamous cell carcinoma
precancerous lesions
platelet derived growth factor receptor-β
immunohistochemistry
