摘要
急性接触低氧环境时,肺血管收缩并分布血流到通气较好的区域,以保持肺内通气/血流比值充分匹配,这一过程称为低氧性肺血管收缩(HPV)。持续低氧状态下,肺血管可发生不可逆性重塑,表现为肺动脉中层平滑肌细胞以及外层纤维细胞增生,导致管腔狭窄,进而引发肺动脉高压(PAH),造成心室后负荷增加,严重者可以引发右心衰竭。肺动脉平滑肌细胞(PASMC)内Ca^2+浓度升高是其收缩、迁移和增殖的重要刺激因素。本文对近年来有关Ca^2+促进HPV方面的研究进行汇总,以期为临床预防低氧和治疗性PAH提供依据。
In acute hypoxia,pulmonary vascular will contract and divert blood to better ventilated area to optimize ventilation/perfusion matching,which is known as hypoxic pulmonary vasoconstriction(HPV).In chronic hypoxia,irreversible pulmonary vascular remodeling can be induced,characterized by pulmonary artery middle smooth muscle cells and the outer fiber cell hyperplasia in luminal stenosis and pulmonary artery hypertension(PAH)eventually.Furthermore,PAH can cause increased ventricular afterload,and right heart failure in severe cases.Pulmonary artery smooth muscle cell(PASMC)elevated Ca2+concentration is one of the most important factors of its contractions,proliferation and migration.Recent studies on Ca^2+promoting in HPV were summarized in order to provide evidence for clinical prevention of hypoxia and therapeutic PAH.
作者
魏冠平
程远
黄煜
何庆
Wei Guanping;Cheng Yuan;Huang Yu;He Qing(Southwest Jiaotong University.Chengdu 610036.Sichuan,China;Department of Emergency,Chengdu Third People's Hospital,Southuest Jiaotong University,Chengdu 610036.Sichuan,China)
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2019年第5期647-649,共3页
Chinese Critical Care Medicine
基金
国家自然科学基金青年基金(81501640).
关键词
低氧性肺血管收缩
低氧性肺动脉高压
肺动脉平滑肌细胞
瞬时受体电位通道
电压门控钙通道
钙库操纵性钙通道
受体操纵性钙通道
Hypoxic pulmonary vasoconstriction
Hypoxic pulmonary hypertension
Pulmonary artery smooth muscle cell
Transient receptor potential channel
Voltage operated calcium channel
Store operated calcium channel
Receptor operated calcium channel
