摘要
低氧性肺动脉高压是与肺动脉平滑肌细胞增殖和血管重塑相关的疾病,持续缺氧诱导引发肺血管收缩和血管重塑。肺血管的收缩和重塑与钙离子浓度密切相关,因此研究钙通道参与的肺血管收缩和血管重塑对低氧性肺动脉高压的发生和发展有重要作用。目前研究发现,抵抗素样分子家族可能通过钙通道参与低氧性肺动脉高压的发病,故探究抵抗素样分子家族与钙通道在低氧性肺动脉高压中的作用机制对治疗低氧性肺动脉高起重要作用。
Hypoxic pulmonary hypertension (HPH) is associated with pulmonary artery smooth muscle cell proliferation and vascular remodeling, continuous hypoxia can induce pulmonary vasoconstriction and vascular remodeling.Pulmonary vasoconstriction and remodeling are closely related to calcium ion concentration, and therefore it is important to investigate the mechanism that calcium channels involved in pulmonary vasoconstriction and vascular remodeling in the occurrence and development of HPH.Current researches found that the resistin-like molecules family may be involved in the pathogenesis of HPH through calcium channels.Thus, exploring the mechanism of the resistin-like molecules family and calcium channels in HPH plays an important role in the treatment of HPH.
作者
卿琼
胡瑞成
朱黎明
蒋永亮
符代炎
戴爱国
Qing Qiong;Hu Ruicheng;Zhu Liming;Jiang Yongliang;Fu Daiyan;Dai Aiguo(Department of Respiratory Medicine,Hunan Provincial People's Hospital,Affiliated to University of South China,Changsha 410000,China)
出处
《国际呼吸杂志》
2019年第2期147-151,共5页
International Journal of Respiration
基金
国家自然科学基金(81570052).
关键词
钙通道
低氧性肺动脉高压
肺血管重塑
肺血管收缩
抵抗素样分子家族
Calcium channels
Hypoxic pulmonary hypertension
Pulmonary vascular remodeling
Pulmonary vasoconstriction
Rsistin-like molecules family
